Cited 1 times in
Autophagy and redox status in carcinoma of an unknown primary.
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 김도희 | - |
dc.contributor.author | 정우희 | - |
dc.date.accessioned | 2015-01-06T17:23:56Z | - |
dc.date.available | 2015-01-06T17:23:56Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0300-8916 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99904 | - |
dc.description.abstract | AIM AND BACKGROUND: The purpose of the study was to investigate the role and clinical implications of autophagy and reactive oxygen species-related proteins in carcinoma of an unknown primary (CUP). METHODS AND STUDY DESIGN: Tissue microarray was constructed for a total of 77 CUP cases. Immunohistochemical stains conducted were as follows: autophagy-related beclin-1, LC3A, LC3B, and p62; redox-related catalase, thioredoxin reductase, glutathione S-transferase π, thioredoxin-interacting protein, and manganese superoxide dismutase. Immunohistochemical results were then related to their clinicopathologic parameters. RESULTS: The degree of LC3A expression showed a difference according to histologic subtype. In undifferentiated carcinoma, LC3A had the highest expression and adenocarcinoma had the lowest expression (P = 0.021). According to clinical subtype, there was a significant difference between LC3A and glutathione S-transferase π in expression. LC3A had the highest expression in single-organ types and the lowest in intermediate and carcinomatosis types (P = 0.003). Glutathione S-transferase π showed the highest expression in nodal-type tumors and the lowest in carcinomatosis types (P = 0.010). In univariate analysis, shorter overall survival was related to tumor glutathione S-transferase π negativity (P = 0.030). CONCLUSIONS: Different expression levels of the autophagy and reactive oxygen species-related proteins, LC3A and glutathione S-transferase π, were observed according to histologic and/or clinical subtype of carcinoma of an unknown primary. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e118~e129 | - |
dc.relation.isPartOf | TUMORI J | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Apoptosis Regulatory Proteins/analysis | - |
dc.subject.MESH | Autophagy* | - |
dc.subject.MESH | Beclin-1 | - |
dc.subject.MESH | Carrier Proteins/analysis | - |
dc.subject.MESH | Catalase/analysis | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glutathione S-Transferase pi/analysis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Membrane Proteins/analysis | - |
dc.subject.MESH | Microtubule-Associated Proteins/analysis | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasms, Unknown Primary/chemistry* | - |
dc.subject.MESH | Neoplasms, Unknown Primary/metabolism | - |
dc.subject.MESH | Neoplasms, Unknown Primary/pathology* | - |
dc.subject.MESH | Neoplasms, Unknown Primary/therapy | - |
dc.subject.MESH | Oxidation-Reduction* | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Superoxide Dismutase/analysis | - |
dc.subject.MESH | Thioredoxin-Disulfide Reductase/analysis | - |
dc.title | Autophagy and redox status in carcinoma of an unknown primary. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Ji-Ye Kim | - |
dc.contributor.googleauthor | Do Hee Kim | - |
dc.contributor.googleauthor | Woo Hee Jung | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.1700/1636.17924 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A03671 | - |
dc.contributor.localId | A00395 | - |
dc.relation.journalcode | J02764 | - |
dc.identifier.eissn | 2038-2529 | - |
dc.identifier.pmid | 25296602 | - |
dc.identifier.url | http://www.tumorijournal.com/article/autophagy-and-redox-status-in-carcinoma-of-an-unknown-primary | - |
dc.subject.keyword | autophagy | - |
dc.subject.keyword | glutathione S-transferase π | - |
dc.subject.keyword | LC3A | - |
dc.subject.keyword | redox | - |
dc.subject.keyword | unknown primary carcinoma | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Kim, Do Hee | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Kim, Do Hee | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 100 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 118 | - |
dc.citation.endPage | 129 | - |
dc.identifier.bibliographicCitation | TUMORI J, Vol.100(4) : 118-129, 2014 | - |
dc.identifier.rimsid | 53877 | - |
dc.type.rims | ART | - |
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