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Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[F]Mefway

Authors
 Minkyung Lee  ;  Young Hoon Ryu  ;  Won Gil Cho  ;  Tae Joo Jeon  ;  Chul Hyoung Lyoo  ;  Yeo Wool Kang  ;  Soo Jin Lee  ;  Chul Hoon Kim  ;  Dong Goo Kim  ;  Jee Hae Kang  ;  Young Beom Seo  ;  Chi Hoon Yi  ;  Kyochul Lee  ;  Tae Hyun Choi  ;  Jae Yong Choi 
Citation
 APPLIED RADIATION AND ISOTOPES, Vol.94C : 30-34, 2014 
Journal Title
 APPLIED RADIATION AND ISOTOPES 
ISSN
 0969-8043 
Issue Date
2014
MeSH
Animals ; Dopaminergic Neurons/diagnostic imaging ; Dopaminergic Neurons/metabolism* ; Fluorine Radioisotopes/pharmacokinetics ; Hippocampus/diagnostic imaging ; Hippocampus/metabolism* ; Male ; Metabolic Clearance Rate ; Parkinsonian Disorders/diagnostic imaging ; Parkinsonian Disorders/metabolism* ; Piperazines/pharmacokinetics* ; Pyridines/pharmacokinetics* ; Radionuclide Imaging ; Radiopharmaceuticals/pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Receptor, Serotonin, 5-HT1A/metabolism* ; Reproducibility of Results ; Sensitivity and Specificity ; Tissue Distribution
Keywords
6-hydroxydopamine ; Hemiparkinsonian model ; trans-[18F]Mefway ; 5-HT1A receptors ; MicroPET
Abstract
The purpose of the present study is to investigate the relationship between dopaminergic neuron destruction and 5-HT system changes in a hemiparkinsonian rat model. We performed PET imaging studies with trans-[18F]Mefway in a hemiparkinsonian model of unilateral 6-hydroxydopamine (6-OHDA) rats. Region-of-interests (ROIs) were drawn in the hippocampus (HP) and cerebellum (CB). HP uptake, the ratios of specific binding to non-specific binding in the HP, and non-displaceable binding potential (BPND) in the HP were compared between 6-OHDA and control rats. As a result, unilateral 6-OHDA-lesioned rats exhibited significant bilateral reduction of HP uptake and trans-[18F]Mefway BPND compared to the intact control group. Therefore, the results demonstrate that destruction of the dopaminergic system causes the reduction of the serotonergic system.
Full Text
http://www.sciencedirect.com/science/article/pii/S0969804314002516
DOI
10.1016/j.apradiso.2014.06.016
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Goo(김동구)
Kim, Chul Hoon(김철훈) ORCID logo https://orcid.org/0000-0002-7360-429X
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Min Kyung(이민경)
Jeon, Tae Joo(전태주) ORCID logo https://orcid.org/0000-0002-7574-6734
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99780
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