Cited 4 times in
Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[F]Mefway
DC Field | Value | Language |
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dc.contributor.author | 김동구 | - |
dc.contributor.author | 김철훈 | - |
dc.contributor.author | 류철형 | - |
dc.contributor.author | 유영훈 | - |
dc.contributor.author | 이민경 | - |
dc.contributor.author | 전태주 | - |
dc.date.accessioned | 2015-01-06T17:19:56Z | - |
dc.date.available | 2015-01-06T17:19:56Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0969-8043 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99780 | - |
dc.description.abstract | The purpose of the present study is to investigate the relationship between dopaminergic neuron destruction and 5-HT system changes in a hemiparkinsonian rat model. We performed PET imaging studies with trans-[18F]Mefway in a hemiparkinsonian model of unilateral 6-hydroxydopamine (6-OHDA) rats. Region-of-interests (ROIs) were drawn in the hippocampus (HP) and cerebellum (CB). HP uptake, the ratios of specific binding to non-specific binding in the HP, and non-displaceable binding potential (BPND) in the HP were compared between 6-OHDA and control rats. As a result, unilateral 6-OHDA-lesioned rats exhibited significant bilateral reduction of HP uptake and trans-[18F]Mefway BPND compared to the intact control group. Therefore, the results demonstrate that destruction of the dopaminergic system causes the reduction of the serotonergic system. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 30~34 | - |
dc.relation.isPartOf | APPLIED RADIATION AND ISOTOPES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Dopaminergic Neurons/diagnostic imaging | - |
dc.subject.MESH | Dopaminergic Neurons/metabolism* | - |
dc.subject.MESH | Fluorine Radioisotopes/pharmacokinetics | - |
dc.subject.MESH | Hippocampus/diagnostic imaging | - |
dc.subject.MESH | Hippocampus/metabolism* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metabolic Clearance Rate | - |
dc.subject.MESH | Parkinsonian Disorders/diagnostic imaging | - |
dc.subject.MESH | Parkinsonian Disorders/metabolism* | - |
dc.subject.MESH | Piperazines/pharmacokinetics* | - |
dc.subject.MESH | Pyridines/pharmacokinetics* | - |
dc.subject.MESH | Radionuclide Imaging | - |
dc.subject.MESH | Radiopharmaceuticals/pharmacokinetics | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Receptor, Serotonin, 5-HT1A/metabolism* | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Tissue Distribution | - |
dc.title | Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[F]Mefway | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Nuclear Medicine (핵의학) | - |
dc.contributor.googleauthor | Minkyung Lee | - |
dc.contributor.googleauthor | Young Hoon Ryu | - |
dc.contributor.googleauthor | Won Gil Cho | - |
dc.contributor.googleauthor | Tae Joo Jeon | - |
dc.contributor.googleauthor | Chul Hyoung Lyoo | - |
dc.contributor.googleauthor | Yeo Wool Kang | - |
dc.contributor.googleauthor | Soo Jin Lee | - |
dc.contributor.googleauthor | Chul Hoon Kim | - |
dc.contributor.googleauthor | Dong Goo Kim | - |
dc.contributor.googleauthor | Jee Hae Kang | - |
dc.contributor.googleauthor | Young Beom Seo | - |
dc.contributor.googleauthor | Chi Hoon Yi | - |
dc.contributor.googleauthor | Kyochul Lee | - |
dc.contributor.googleauthor | Tae Hyun Choi | - |
dc.contributor.googleauthor | Jae Yong Choi | - |
dc.identifier.doi | 10.1016/j.apradiso.2014.06.016 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00396 | - |
dc.contributor.localId | A01057 | - |
dc.contributor.localId | A01333 | - |
dc.contributor.localId | A02485 | - |
dc.contributor.localId | A02780 | - |
dc.contributor.localId | A03557 | - |
dc.relation.journalcode | J00206 | - |
dc.identifier.eissn | 1872-9800 | - |
dc.identifier.pmid | 25064461 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0969804314002516 | - |
dc.subject.keyword | 6-hydroxydopamine | - |
dc.subject.keyword | Hemiparkinsonian model | - |
dc.subject.keyword | trans-[18F]Mefway | - |
dc.subject.keyword | 5-HT1A receptors | - |
dc.subject.keyword | MicroPET | - |
dc.contributor.alternativeName | Kim, Dong Goo | - |
dc.contributor.alternativeName | Kim, Chul Hoon | - |
dc.contributor.alternativeName | Lyoo, Chul Hyoung | - |
dc.contributor.alternativeName | Ryu, Young Hoon | - |
dc.contributor.alternativeName | Lee, Min Kyung | - |
dc.contributor.alternativeName | Jeon, Tae Joo | - |
dc.contributor.affiliatedAuthor | Kim, Dong Goo | - |
dc.contributor.affiliatedAuthor | Kim, Chul Hoon | - |
dc.contributor.affiliatedAuthor | Lyoo, Chul Hyoung | - |
dc.contributor.affiliatedAuthor | Ryu, Young Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Min Kyung | - |
dc.contributor.affiliatedAuthor | Jeon, Tae Joo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 94C | - |
dc.citation.startPage | 30 | - |
dc.citation.endPage | 34 | - |
dc.identifier.bibliographicCitation | APPLIED RADIATION AND ISOTOPES, Vol.94C : 30-34, 2014 | - |
dc.identifier.rimsid | 49594 | - |
dc.type.rims | ART | - |
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