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Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[F]Mefway

DC FieldValueLanguage
dc.contributor.author김동구-
dc.contributor.author김철훈-
dc.contributor.author류철형-
dc.contributor.author유영훈-
dc.contributor.author이민경-
dc.contributor.author전태주-
dc.date.accessioned2015-01-06T17:19:56Z-
dc.date.available2015-01-06T17:19:56Z-
dc.date.issued2014-
dc.identifier.issn0969-8043-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99780-
dc.description.abstractThe purpose of the present study is to investigate the relationship between dopaminergic neuron destruction and 5-HT system changes in a hemiparkinsonian rat model. We performed PET imaging studies with trans-[18F]Mefway in a hemiparkinsonian model of unilateral 6-hydroxydopamine (6-OHDA) rats. Region-of-interests (ROIs) were drawn in the hippocampus (HP) and cerebellum (CB). HP uptake, the ratios of specific binding to non-specific binding in the HP, and non-displaceable binding potential (BPND) in the HP were compared between 6-OHDA and control rats. As a result, unilateral 6-OHDA-lesioned rats exhibited significant bilateral reduction of HP uptake and trans-[18F]Mefway BPND compared to the intact control group. Therefore, the results demonstrate that destruction of the dopaminergic system causes the reduction of the serotonergic system.-
dc.description.statementOfResponsibilityopen-
dc.format.extent30~34-
dc.relation.isPartOfAPPLIED RADIATION AND ISOTOPES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHDopaminergic Neurons/diagnostic imaging-
dc.subject.MESHDopaminergic Neurons/metabolism*-
dc.subject.MESHFluorine Radioisotopes/pharmacokinetics-
dc.subject.MESHHippocampus/diagnostic imaging-
dc.subject.MESHHippocampus/metabolism*-
dc.subject.MESHMale-
dc.subject.MESHMetabolic Clearance Rate-
dc.subject.MESHParkinsonian Disorders/diagnostic imaging-
dc.subject.MESHParkinsonian Disorders/metabolism*-
dc.subject.MESHPiperazines/pharmacokinetics*-
dc.subject.MESHPyridines/pharmacokinetics*-
dc.subject.MESHRadionuclide Imaging-
dc.subject.MESHRadiopharmaceuticals/pharmacokinetics-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReceptor, Serotonin, 5-HT1A/metabolism*-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHTissue Distribution-
dc.titleDopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[F]Mefway-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Nuclear Medicine (핵의학)-
dc.contributor.googleauthorMinkyung Lee-
dc.contributor.googleauthorYoung Hoon Ryu-
dc.contributor.googleauthorWon Gil Cho-
dc.contributor.googleauthorTae Joo Jeon-
dc.contributor.googleauthorChul Hyoung Lyoo-
dc.contributor.googleauthorYeo Wool Kang-
dc.contributor.googleauthorSoo Jin Lee-
dc.contributor.googleauthorChul Hoon Kim-
dc.contributor.googleauthorDong Goo Kim-
dc.contributor.googleauthorJee Hae Kang-
dc.contributor.googleauthorYoung Beom Seo-
dc.contributor.googleauthorChi Hoon Yi-
dc.contributor.googleauthorKyochul Lee-
dc.contributor.googleauthorTae Hyun Choi-
dc.contributor.googleauthorJae Yong Choi-
dc.identifier.doi10.1016/j.apradiso.2014.06.016-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00396-
dc.contributor.localIdA01057-
dc.contributor.localIdA01333-
dc.contributor.localIdA02485-
dc.contributor.localIdA02780-
dc.contributor.localIdA03557-
dc.relation.journalcodeJ00206-
dc.identifier.eissn1872-9800-
dc.identifier.pmid25064461-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0969804314002516-
dc.subject.keyword6-hydroxydopamine-
dc.subject.keywordHemiparkinsonian model-
dc.subject.keywordtrans-[18F]Mefway-
dc.subject.keyword5-HT1A receptors-
dc.subject.keywordMicroPET-
dc.contributor.alternativeNameKim, Dong Goo-
dc.contributor.alternativeNameKim, Chul Hoon-
dc.contributor.alternativeNameLyoo, Chul Hyoung-
dc.contributor.alternativeNameRyu, Young Hoon-
dc.contributor.alternativeNameLee, Min Kyung-
dc.contributor.alternativeNameJeon, Tae Joo-
dc.contributor.affiliatedAuthorKim, Dong Goo-
dc.contributor.affiliatedAuthorKim, Chul Hoon-
dc.contributor.affiliatedAuthorLyoo, Chul Hyoung-
dc.contributor.affiliatedAuthorRyu, Young Hoon-
dc.contributor.affiliatedAuthorLee, Min Kyung-
dc.contributor.affiliatedAuthorJeon, Tae Joo-
dc.rights.accessRightsfree-
dc.citation.volume94C-
dc.citation.startPage30-
dc.citation.endPage34-
dc.identifier.bibliographicCitationAPPLIED RADIATION AND ISOTOPES, Vol.94C : 30-34, 2014-
dc.identifier.rimsid49594-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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