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Spatial epidemiology of dry eye disease: findings from South Korea

Authors
 Sun-Bi Um  ;  Na Hyun Kim  ;  Hyung Keun Lee  ;  Jong Suk Song  ;  Hyeon Chang Kim 
Citation
 INTERNATIONAL JOURNAL OF HEALTH GEOGRAPHICS, Vol.13(31) : 1-9, 2014 
Journal Title
 INTERNATIONAL JOURNAL OF HEALTH GEOGRAPHICS 
Issue Date
2014
MeSH
Adult ; Aged ; Air Pollution/adverse effects ; Air Pollution/analysis ; Dry Eye Syndromes/diagnosis ; Dry Eye Syndromes/epidemiology* ; Environmental Exposure/adverse effects* ; Female ; Geographic Mapping* ; Humans ; Humidity/adverse effects ; Male ; Middle Aged ; Nutrition Surveys/methods ; Republic of Korea/epidemiology ; Risk Factors ; Spatio-Temporal Analysis* ; Sunlight/adverse effects
Keywords
Air pollutants ; Dry eye disease ; Meteorological factors ; Prevalence ; Spatial epidemiology
Abstract
BACKGROUND: DED rate maps from diverse regions may allow us to understand world-wide spreading pattern of the disease. Only few studies compared the prevalence of DED between geographical regions in non-spatial context. Therefore, we examined the spatial epidemiological pattern of DED prevalence in South Korea using a nationally representative sample. METHODS: We analyzed 16,431 Korean adults aged 30 years or older of the 5th Korea National Health and Nutrition Examination Survey. DED was defined as previously diagnosed by an ophthalmologist as well as symptoms experienced. Multiple logistic regression analysis was used to assess the spatial pattern in the prevalence of DED, and effects of environmental factors. RESULTS: Among seven metropolitan cities and nine provinces, three metropolitan cities located in the southeast of Korea revealed the highest prevalence of DED. After adjusting for sex, age and survey year, people living in urban areas had higher risk of having DED. Adjusted odds ratio for having previously diagnosed DED was 1.677 (95% CI 1.299-2.166) for metropolitan cities and 1.580 (95% CI 1.215-2.055) for other cities compared to rural areas. Corresponding odds ratio for presenting DED symptoms was 1.388 (95% CI 1.090-1.766) for metropolitan cities and 1.271 (95% CI 0.999-1.617) for other cities. Lower humidity and longer sunshine duration were significantly associated with DED. Among air pollutants, SO2 was associated with DED, while NO2, O3, CO, and PM10 were not. CONCLUSION: Our findings suggest that prevalence of DED can be affected by the degree of urbanization and environmental factors such as humidity and sunshine duration.
Files in This Item:
T201403163.pdf Download
DOI
10.1186/1476-072X-13-31
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Lee, Hyung Keun(이형근) ORCID logo https://orcid.org/0000-0002-1123-2136
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99760
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