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Low Serum Vitamin D Is Associated with Anti-Thyroid Peroxidase Antibody in Autoimmune Thyroiditis

Authors
 Dong Yeob Shin  ;  Kwang Joon Kim  ;  Daham Kim  ;  Sena Hwang  ;  Eun Jig Lee 
Citation
 YONSEI MEDICAL JOURNAL, Vol.55(2) : 476-481, 2014 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2014
MeSH
Adult ; Antibodies/blood ; Body Mass Index ; Calcifediol/blood ; Female ; Humans ; Iodide Peroxidase/immunology* ; Male ; Middle Aged ; Regression Analysis ; Retrospective Studies ; Thyroid Function Tests ; Thyroiditis, Autoimmune/blood* ; Thyroiditis, Autoimmune/diagnostic imaging ; Thyroiditis, Autoimmune/immunology* ; Ultrasonography ; Vitamin D/blood*
Keywords
Vitamin D deficiency ; anti-thyroid peroxidase antibody ; autoimmune thyroiditis
Abstract
PURPOSE: The association between autoimmune thyroid diseases (AITDs) and vitamin D deficiency is controversial. We aimed to evaluate the relationship between serum 25-hydroxy-vitamin D3 [25(OH)D3] and anti-thyroid antibody levels. MATERIALS AND METHODS: 25(OH)D3, anti-thyroid antibodies, and thyroid function measured in 304 patients who visited the endocrinology clinic were analyzed. The patients were subgrouped into the AITDs or non-AITDs category according to the presence or absence of anti-thyroid antibodies. The relationship between anti-thyroid peroxidase antibody (TPOAb) and 25(OH)D3 was evaluated. RESULTS: The patients with elevated anti-thyroid antibodies had lower levels of serum 25(OH)D3 than those who did not (12.6±5.5 ng/mL vs. 14.5±7.3 ng/mL, respectively, p<0.001). Importantly, after adjusting for age, sex, and body mass index, a negative correlation (r=-0.252, p<0.001) was recognized between 25(OH)D3 and TPOAb levels in the AITDs group, but this correlation did not exist in the non-AITDs group (r=0.117, p=0.127). 25(OH)D3 level was confirmed as an independent factor after adjusting for co-factors that may affect the presence of TPOAb in the AITDs group. CONCLUSION: 25(OH)D3 level is an independent factor affecting the presence of TPOAb in AITDs. The causal effect of 25(OH)D3 deficiency to AITDs is to be elucidated.
Files in This Item:
T201403133.pdf Download
DOI
10.3349/ymj.2014.55.2.476
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kwang Joon(김광준) ORCID logo https://orcid.org/0000-0002-5554-8255
Kim, Daham(김다함) ORCID logo https://orcid.org/0000-0003-1871-686X
Shin, Dong Yeob(신동엽) ORCID logo https://orcid.org/0000-0003-1048-7978
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
Hwang, Se Na(황세나)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99730
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