Cited 83 times in
Low Serum Vitamin D Is Associated with Anti-Thyroid Peroxidase Antibody in Autoimmune Thyroiditis
DC Field | Value | Language |
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dc.contributor.author | 김다함 | - |
dc.contributor.author | 신동엽 | - |
dc.contributor.author | 이은직 | - |
dc.contributor.author | 황세나 | - |
dc.contributor.author | 김광준 | - |
dc.date.accessioned | 2015-01-06T17:18:23Z | - |
dc.date.available | 2015-01-06T17:18:23Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99730 | - |
dc.description.abstract | PURPOSE: The association between autoimmune thyroid diseases (AITDs) and vitamin D deficiency is controversial. We aimed to evaluate the relationship between serum 25-hydroxy-vitamin D3 [25(OH)D3] and anti-thyroid antibody levels. MATERIALS AND METHODS: 25(OH)D3, anti-thyroid antibodies, and thyroid function measured in 304 patients who visited the endocrinology clinic were analyzed. The patients were subgrouped into the AITDs or non-AITDs category according to the presence or absence of anti-thyroid antibodies. The relationship between anti-thyroid peroxidase antibody (TPOAb) and 25(OH)D3 was evaluated. RESULTS: The patients with elevated anti-thyroid antibodies had lower levels of serum 25(OH)D3 than those who did not (12.6±5.5 ng/mL vs. 14.5±7.3 ng/mL, respectively, p<0.001). Importantly, after adjusting for age, sex, and body mass index, a negative correlation (r=-0.252, p<0.001) was recognized between 25(OH)D3 and TPOAb levels in the AITDs group, but this correlation did not exist in the non-AITDs group (r=0.117, p=0.127). 25(OH)D3 level was confirmed as an independent factor after adjusting for co-factors that may affect the presence of TPOAb in the AITDs group. CONCLUSION: 25(OH)D3 level is an independent factor affecting the presence of TPOAb in AITDs. The causal effect of 25(OH)D3 deficiency to AITDs is to be elucidated. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 476~481 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antibodies/blood | - |
dc.subject.MESH | Body Mass Index | - |
dc.subject.MESH | Calcifediol/blood | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Iodide Peroxidase/immunology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Regression Analysis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Thyroid Function Tests | - |
dc.subject.MESH | Thyroiditis, Autoimmune/blood* | - |
dc.subject.MESH | Thyroiditis, Autoimmune/diagnostic imaging | - |
dc.subject.MESH | Thyroiditis, Autoimmune/immunology* | - |
dc.subject.MESH | Ultrasonography | - |
dc.subject.MESH | Vitamin D/blood* | - |
dc.title | Low Serum Vitamin D Is Associated with Anti-Thyroid Peroxidase Antibody in Autoimmune Thyroiditis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Dong Yeob Shin | - |
dc.contributor.googleauthor | Kwang Joon Kim | - |
dc.contributor.googleauthor | Daham Kim | - |
dc.contributor.googleauthor | Sena Hwang | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.identifier.doi | 10.3349/ymj.2014.55.2.476 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02093 | - |
dc.contributor.localId | A03050 | - |
dc.contributor.localId | A04468 | - |
dc.contributor.localId | A00363 | - |
dc.contributor.localId | A00317 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 24532520 | - |
dc.subject.keyword | Vitamin D deficiency | - |
dc.subject.keyword | anti-thyroid peroxidase antibody | - |
dc.subject.keyword | autoimmune thyroiditis | - |
dc.contributor.alternativeName | Kim, Da Ham | - |
dc.contributor.alternativeName | Shin, Dong Yeob | - |
dc.contributor.alternativeName | Lee, Eun Jig | - |
dc.contributor.alternativeName | Hwang, Se Na | - |
dc.contributor.affiliatedAuthor | Shin, Dong Yeob | - |
dc.contributor.affiliatedAuthor | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | Hwang, Se Na | - |
dc.contributor.affiliatedAuthor | Kim, Da Ham | - |
dc.contributor.affiliatedAuthor | Kim, Kwang Joon | - |
dc.citation.volume | 55 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 476 | - |
dc.citation.endPage | 481 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.55(2) : 476-481, 2014 | - |
dc.identifier.rimsid | 57085 | - |
dc.type.rims | ART | - |
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