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Low Serum Vitamin D Is Associated with Anti-Thyroid Peroxidase Antibody in Autoimmune Thyroiditis

DC FieldValueLanguage
dc.contributor.author김다함-
dc.contributor.author신동엽-
dc.contributor.author이은직-
dc.contributor.author황세나-
dc.contributor.author김광준-
dc.date.accessioned2015-01-06T17:18:23Z-
dc.date.available2015-01-06T17:18:23Z-
dc.date.issued2014-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99730-
dc.description.abstractPURPOSE: The association between autoimmune thyroid diseases (AITDs) and vitamin D deficiency is controversial. We aimed to evaluate the relationship between serum 25-hydroxy-vitamin D3 [25(OH)D3] and anti-thyroid antibody levels. MATERIALS AND METHODS: 25(OH)D3, anti-thyroid antibodies, and thyroid function measured in 304 patients who visited the endocrinology clinic were analyzed. The patients were subgrouped into the AITDs or non-AITDs category according to the presence or absence of anti-thyroid antibodies. The relationship between anti-thyroid peroxidase antibody (TPOAb) and 25(OH)D3 was evaluated. RESULTS: The patients with elevated anti-thyroid antibodies had lower levels of serum 25(OH)D3 than those who did not (12.6±5.5 ng/mL vs. 14.5±7.3 ng/mL, respectively, p<0.001). Importantly, after adjusting for age, sex, and body mass index, a negative correlation (r=-0.252, p<0.001) was recognized between 25(OH)D3 and TPOAb levels in the AITDs group, but this correlation did not exist in the non-AITDs group (r=0.117, p=0.127). 25(OH)D3 level was confirmed as an independent factor after adjusting for co-factors that may affect the presence of TPOAb in the AITDs group. CONCLUSION: 25(OH)D3 level is an independent factor affecting the presence of TPOAb in AITDs. The causal effect of 25(OH)D3 deficiency to AITDs is to be elucidated.-
dc.description.statementOfResponsibilityopen-
dc.format.extent476~481-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAntibodies/blood-
dc.subject.MESHBody Mass Index-
dc.subject.MESHCalcifediol/blood-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIodide Peroxidase/immunology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRegression Analysis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHThyroid Function Tests-
dc.subject.MESHThyroiditis, Autoimmune/blood*-
dc.subject.MESHThyroiditis, Autoimmune/diagnostic imaging-
dc.subject.MESHThyroiditis, Autoimmune/immunology*-
dc.subject.MESHUltrasonography-
dc.subject.MESHVitamin D/blood*-
dc.titleLow Serum Vitamin D Is Associated with Anti-Thyroid Peroxidase Antibody in Autoimmune Thyroiditis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorDong Yeob Shin-
dc.contributor.googleauthorKwang Joon Kim-
dc.contributor.googleauthorDaham Kim-
dc.contributor.googleauthorSena Hwang-
dc.contributor.googleauthorEun Jig Lee-
dc.identifier.doi10.3349/ymj.2014.55.2.476-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02093-
dc.contributor.localIdA03050-
dc.contributor.localIdA04468-
dc.contributor.localIdA00363-
dc.contributor.localIdA00317-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid24532520-
dc.subject.keywordVitamin D deficiency-
dc.subject.keywordanti-thyroid peroxidase antibody-
dc.subject.keywordautoimmune thyroiditis-
dc.contributor.alternativeNameKim, Da Ham-
dc.contributor.alternativeNameShin, Dong Yeob-
dc.contributor.alternativeNameLee, Eun Jig-
dc.contributor.alternativeNameHwang, Se Na-
dc.contributor.affiliatedAuthorShin, Dong Yeob-
dc.contributor.affiliatedAuthorLee, Eun Jig-
dc.contributor.affiliatedAuthorHwang, Se Na-
dc.contributor.affiliatedAuthorKim, Da Ham-
dc.contributor.affiliatedAuthorKim, Kwang Joon-
dc.citation.volume55-
dc.citation.number2-
dc.citation.startPage476-
dc.citation.endPage481-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.55(2) : 476-481, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers

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