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Differential association between metabolic syndrome and coronary artery disease evaluated with cardiac computed tomography according to the presence of diabetes in a symptomatic Korean population

DC FieldValueLanguage
dc.contributor.author김영진-
dc.contributor.author성지민-
dc.contributor.author신상훈-
dc.contributor.author심지영-
dc.contributor.author원기범-
dc.contributor.author장혁재-
dc.contributor.author정남식-
dc.contributor.author조인정-
dc.contributor.author최병욱-
dc.contributor.author홍그루-
dc.date.accessioned2015-01-06T17:15:33Z-
dc.date.available2015-01-06T17:15:33Z-
dc.date.issued2014-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99638-
dc.description.abstractBACKGROUND: Metabolic syndrome (MetS) is associated with increased risks of diabetes and coronary artery disease (CAD). Despite the controversial inclusion of established diabetes in MetS, the association between MetS and CAD according to diabetes status has not been elucidated in the Asian population. METHODS: We evaluated the association between MetS and CAD using the parameters including any plaque, obstructive plaque, and coronary artery calcium score (CACS) >100 according to diabetes status in 2,869 symptomatic Korean subjects who underwent cardiac computed tomographic angiography. RESULTS: The prevalence of MetS was significantly higher in the diabetic subjects than in the non-diabetic subjects (69% vs. 34%, P <0.001). The incidence of any plaque (64% vs. 43%, P <0.001), obstructive plaque (26% vs. 13%, P = 0.006), and CACS >100 (23% vs. 12%, P = 0.012) was significantly higher in diabetic subjects than in non-diabetic subjects. Among the MetS components, decreased high-density lipoprotein level was significantly associated with any plaque (odds ratio [OR] 1.35), obstructive plaque (OR 1.55), and CACS >100 (OR 1.57) in the non-diabetic subjects (P <0.01, respectively). However, none of the MetS components were associated with all the parameters in the diabetic subjects. Multivariate regression analysis revealed that MetS and the number of MetS components (MetSN) were independently associated with any plaque (MetS: OR 1.55, P <0.001; MetSN: OR 1.22, P <0.001), obstructive plaque (MetS: OR 1.52, P = 0.003; MetSN: OR 1.25, P <0.001), and CACS >100 (MetS: OR 1.46, P = 0.015; MetSN: OR 1.21, P = 0.004) only in the non-diabetic subjects, respectively. CONCLUSIONS: MetS was independently associated with the presence and severity of CAD only in the non-diabetic subjects among the symptomatic Korean population.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1~10-
dc.relation.isPartOfBMC CARDIOVASCULAR DISORDERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHCoronary Angiography/methods*-
dc.subject.MESHCoronary Artery Disease/diagnostic imaging*-
dc.subject.MESHCoronary Artery Disease/epidemiology*-
dc.subject.MESHCoronary Vessels/diagnostic imaging*-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHDiabetes Mellitus/diagnosis-
dc.subject.MESHDiabetes Mellitus/epidemiology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHLipoproteins, HDL/blood-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHMetabolic Syndrome/blood-
dc.subject.MESHMetabolic Syndrome/diagnosis-
dc.subject.MESHMetabolic Syndrome/epidemiology*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultidetector Computed Tomography*-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPlaque, Atherosclerotic-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPrevalence-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRisk Factors-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHVascular Calcification/diagnostic imaging-
dc.subject.MESHVascular Calcification/epidemiology-
dc.titleDifferential association between metabolic syndrome and coronary artery disease evaluated with cardiac computed tomography according to the presence of diabetes in a symptomatic Korean population-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentYonsei Cardiovascular Research Institute (심혈관연구소)-
dc.contributor.googleauthorKi-Bum Won-
dc.contributor.googleauthorHyuk-Jae Chang-
dc.contributor.googleauthorJimin Sung-
dc.contributor.googleauthorSanghoon Shin-
dc.contributor.googleauthorIn-Jeong Cho-
dc.contributor.googleauthorChi-Young Shim-
dc.contributor.googleauthorGeu-Ru Hong-
dc.contributor.googleauthorYoung Jin Kim-
dc.contributor.googleauthorByung-Wook Choi-
dc.contributor.googleauthorNamsik Chung-
dc.identifier.doi10.1186/1471-2261-14-105-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02107-
dc.contributor.localIdA02213-
dc.contributor.localIdA02429-
dc.contributor.localIdA03490-
dc.contributor.localIdA03585-
dc.contributor.localIdA03892-
dc.contributor.localIdA04059-
dc.contributor.localIdA04386-
dc.contributor.localIdA00727-
dc.contributor.localIdA01955-
dc.relation.journalcodeJ00352-
dc.identifier.eissn1471-2261-
dc.identifier.pmid25138993-
dc.subject.keywordMetabolic syndrome-
dc.subject.keywordDiabetes-
dc.subject.keywordCoronary artery disease-
dc.subject.keywordCoronary computed tomographic angiography-
dc.contributor.alternativeNameKim, Young Jin-
dc.contributor.alternativeNameSung, Ji Min-
dc.contributor.alternativeNameShin, Sang Hoon-
dc.contributor.alternativeNameShim, Chi Young-
dc.contributor.alternativeNameWon, Ki Bum-
dc.contributor.alternativeNameChang, Hyuck Jae-
dc.contributor.alternativeNameChung, Nam Sik-
dc.contributor.alternativeNameCho, In Jeong-
dc.contributor.alternativeNameChoi, Byoung Wook-
dc.contributor.alternativeNameHong, Geu Ru-
dc.contributor.affiliatedAuthorShin, Sang Hoon-
dc.contributor.affiliatedAuthorShim, Chi Young-
dc.contributor.affiliatedAuthorWon, Ki Bum-
dc.contributor.affiliatedAuthorChang, Hyuck Jae-
dc.contributor.affiliatedAuthorChung, Nam Sik-
dc.contributor.affiliatedAuthorCho, In Jeong-
dc.contributor.affiliatedAuthorChoi, Byoung Wook-
dc.contributor.affiliatedAuthorHong, Geu Ru-
dc.contributor.affiliatedAuthorKim, Young Jin-
dc.contributor.affiliatedAuthorSung, Ji Min-
dc.citation.volume14-
dc.citation.number105-
dc.citation.startPage1-
dc.citation.endPage10-
dc.identifier.bibliographicCitationBMC CARDIOVASCULAR DISORDERS, Vol.14(105) : 1-10, 2014-
Appears in Collections:
5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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