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Short-term effects of erythropoietin on neurodevelopment in infants with cerebral palsy: A pilot study

 Hee Song Lee  ;  Junyoung Song  ;  Kyunghoon Min  ;  Yong-Soo Choi  ;  Sun-Mi Kim  ;  Sung-Rae Cho  ;  MinYoung Kim 
 BRAIN & DEVELOPMENT, Vol.36(9) : 764-769, 2014 
Journal Title
Issue Date
Anti-Inflammatory Agents/administration & dosage* ; Cerebral Palsy/drug therapy* ; Cerebral Palsy/physiopathology ; Cerebral Palsy/rehabilitation ; Child Development/drug effects* ; Erythropoietin/administration & dosage* ; Female ; Humans ; Infant ; Male ; Motor Activity/drug effects ; Pilot Projects ; Recombinant Proteins/administration & dosage* ; Time Factors ; Treatment Outcome
Anti-inflammatory effect ; Cerebral palsy ; Neurodevelopment ; Recombinant human erythropoietin
Objective: Cerebral palsy (CP) is a disabling condition characterized by the motor impairment, which is difficult to be ameliorated. In the brain of infants with CP, there are persistent pathomechanisms including accentuated neuroinflammation. Since erythropoietin was demonstrated to have neuroprotective effect via anti-inflammatory and anti-apoptotic properties, we hypothesized that the administration of recombinant human EPO (rhEPO) could help children with CP, especially young infants. Materials and method: We investigated the therapeutic efficacy of rhEPO for infants with CP, who had been undergoing active rehabilitation in hospitalized setting to eliminate treatment bias. Twenty infants with CP were randomly divided into EPO or control group equally. We compared the changes in the Gross Motor Function Measure (GMFM) and the Bayley Scales of Infant Development-II (BSID-II) scores during one month of hospitalization between two groups. Results: The improvements after 1 month on the GMFM A and GMFM total scores differed significantly between the groups (p = 0.003, p = 0.04, respectively). However, the changes after 6 months were not different between the two groups. The scores of BSID-II did not show any differences at 1-month and 6-months post-treatment. Conclusion: These results indicated that rhEPO could have therapeutic efficacy for infants with CP during the active rehabilitation and anti-inflammation was suggested to be one of its therapeutic mechanisms.
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1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Cho, Sung-Rae(조성래) ORCID logo https://orcid.org/0000-0003-1429-2684
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