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Photoacoustic Imaging of Breast Microcalcifications: A Preliminary Study with 8-Gauge Core-Biopsied Breast Specimens

Authors
 Ga Ram Kim  ;  Jeeun Kang  ;  Jin Young Kwak  ;  Jin Ho Chang  ;  Seung Il Kim  ;  Ji Hyun Youk  ;  Hee Jung Moon  ;  Min Jung Kim  ;  Eun-Kyung Kim 
Citation
 PLOS ONE, Vol.9(8) : e105878, 2014 
Journal Title
 PLOS ONE 
Issue Date
2014
MeSH
Adult ; Aged ; Biopsy, Large-Core Needle ; Breast/pathology* ; Breast Diseases/pathology* ; Breast Neoplasms/pathology* ; Calcinosis/pathology* ; Diagnostic Imaging/methods* ; Female ; Humans ; Middle Aged ; Photoacoustic Techniques/methods* ; Young Adult
Abstract
BACKGROUND: We presented the photoacoustic imaging (PAI) tool and to evaluate whether microcalcifications in breast tissue can be detected on photoacoustic (PA) images. METHODS: We collected 21 cores containing microcalcifications (n = 11, microcalcification group) and none (n = 10, control group) in stereotactic or ultrasound (US) guided 8-gauge vacuum-assisted biopsies. Photoacoustic (PA) images were acquired through ex vivo experiments by transmitting laser pulses with two different wavelengths (700 nm and 800 nm). The presence of microcalcifications in PA images were blindly assessed by two radiologists and compared with specimen mammography. A ratio of the signal amplitude occurring at 700 nm to that occurring at 800 nm was calculated for each PA focus and was called the PAI ratio. RESULTS: Based on the change of PA signal amplitude between 700 nm and 800 nm, 10 out of 11 specimens containing microcalcifications and 8 out of 10 specimens without calcifications were correctly identified on blind review; the sensitivity, specificity, accuracy, positive predictive and negative predictive values of our blind review were 90.91%, 80.0%, 85.71%, 83.33% and 88.89%. The PAI ratio in the microcalcification group was significantly higher than that in the control group (the median PAI ratio, 2.46 versus 1.11, respectively, P =  .001). On subgroup analysis in the microcalcification group, neither malignant diagnosis nor the number or size of calcification-foci was proven to contribute to PAI ratios. CONCLUSION: Breast microcalcifications generated distinguishable PA signals unlike breast tissue without calcifications. So, PAI, a non-ionizing and non-invasive hybrid imaging technique, can be an alternative in overcoming the limitations of conventional US imaging.
Files in This Item:
T201402686.pdf Download
DOI
10.1371/journal.pone.0105878
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Ga Ram(김가람) ORCID logo https://orcid.org/0000-0002-4481-5792
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0003-4949-1237
Kim, Seung Il(김승일)
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Youk, Ji Hyun(육지현) ORCID logo https://orcid.org/0000-0002-7787-780X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99486
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