2 215

Cited 5 times in

Altered structural connectivity and trait anhedonia in patients withschizophrenia

Authors
 Jung Suk Lee  ;  Kiwan Han  ;  Seung-Koo Lee  ;  Jeong-Ho Seok  ;  Jae-Jin Kim 
Citation
 NEUROSCIENCE LETTERS, Vol.579 : 7-11, 2014 
Journal Title
 NEUROSCIENCE LETTERS 
ISSN
 0304-3940 
Issue Date
2014
MeSH
Adult ; Anhedonia* ; Anisotropy ; Diffusion Magnetic Resonance Imaging ; Female ; Gray Matter/pathology ; Humans ; Male ; Nerve Net/pathology ; Neural Pathways/pathology* ; Reward ; Schizophrenia/pathology* ; Schizophrenic Psychology* ; White Matter/pathology
Keywords
Cingulum ; Diffusion tensor imaging ; Schizophrenia ; Superior longitudinal fasciculus ; Trait anhedonia
Abstract
This study tested association between anhedonia scores and white matter integrity in order to investigate the neural basis of trait anhedonia in schizophrenia. A total of 31 patients with schizophrenia and 33 healthy controls underwent diffusion weighted imaging and scoring of trait anhedonia using the Physical Anhedonia Scale. Using tract-based spatial statistics, we found that fractional anisotropy values of some white matter regions were differently correlated with Physical Anhedonia Scale scores between the two groups. The white matter regions that were more significantly correlated with trait anhedonia in patients than in controls included the left side of the cingulum, splenium of the corpus callosum, inferior longitudinal fasciculus, superior longitudinal fasciculus I and II, anterior thalamic radiation, and optic radiation. Of these regions, fractional anisotropy values in the cingulum and superior longitudinal fasciculus II were positively correlated with trait anhedonia in patients with schizophrenia. These findings suggest that alterations in structural connectivity within large-scale brain networks, including the default mode and central executive networks, may contribute to the development of trait anhedonia in patients with schizophrenia.
Full Text
http://www.sciencedirect.com/science/article/pii/S0304394014005576
DOI
10.1016/j.neulet.2014.07.001
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Seok, Jeong Ho(석정호) ORCID logo https://orcid.org/0000-0002-9402-7591
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Lee, Jung Suk(이정석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99452
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse