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The Impact of Obesity on Subclinical Coronary Atherosclerosis According to the Risk of Cardiovascular Disease

Authors
 Seung-Yul Lee  ;  Hyuk-Jae Chang  ;  Jimin Sung  ;  Kwang Joon Kim  ;  Sanghoon Shin  ;  In-Jeong Cho  ;  Chi Young Shim  ;  Geu-Ru Hong  ;  Namsik Chung 
Citation
 OBESITY, Vol.22(7) : 1762-1768, 2014 
Journal Title
 OBESITY 
ISSN
 1930-7381 
Issue Date
2014
MeSH
Abdominal Fat/diagnostic imaging ; Adult ; Aged ; Body Mass Index ; Cardiovascular Diseases/diagnosis* ; Cardiovascular Diseases/diagnostic imaging ; Cardiovascular Diseases/epidemiology* ; Coronary Artery Disease/diagnosis* ; Coronary Artery Disease/epidemiology* ; Female ; Humans ; Male ; Middle Aged ; Multidetector Computed Tomography ; Obesity/complications* ; Obesity/epidemiology* ; Risk
Abstract
OBJECTIVE: To evaluate whether the association of obesity with coronary atherosclerosis depends on the risk of cardiovascular disease (CVD). METHODS: A total of 1,406 asymptomatic Korean adults underwent both cardiac and abdominal multislice computed tomography (MSCT) as part of a routine health check-up. Obesity was measured using body mass index (BMI), waist circumference (WC), and MSCT-derived area/ratio of visceral and subcutaneous fat. The burden of CVD risk was assessed by the Framingham risk equation. RESULTS: In the low-risk group for CVD, obesity measurements (standardized odds ratio, 95% confidence interval) of BMI (1.406, 1.197-1.652), WC (1.707, 1.434-2.032), visceral fat area (1.700, 1.438-2.009), and visceral-to-subcutaneous fat ratio (1.620, 1.379-1.903) were associated with the presence of coronary calcification after adjusting for traditional CVD risks. But in the moderate-to-high risk group, the associations were attenuated. For additional adjustments of obesity measurements, in the low-risk group, WC (1.717, 1.172-2.514) and visceral-to-subcutaneous fat ratio (1.400, 1.029-1.904) were independent determinants of coronary calcification. CONCLUSIONS: Obesity is differentially associated with subclinical coronary atherosclerosis, according to the burden of CVD risk. In low-risk adults, the relative distribution of abdominal fat, as well as whole body fat, is important to coronary atherosclerosis.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/oby.20760/abstract
DOI
10.1002/oby.20760
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers
Yonsei Authors
Sung, Ji Min(성지민)
Shin, Sang Hoon(신상훈)
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
Chang, Hyuk-Jae(장혁재) ORCID logo https://orcid.org/0000-0002-6139-7545
Chung, Nam Sik(정남식)
Cho, In Jeong(조인정)
Hong, Geu Ru(홍그루) ORCID logo https://orcid.org/0000-0003-4981-3304
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99440
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