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Brachial-ankle pulse wave velocity for predicting functional outcome in acute stroke

 Jinkwon Kim  ;  Tae-Jin Song  ;  Eun Hye Kim  ;  Ki Jeong Lee  ;  Hye Sun Lee  ;  Chung Mo Nam  ;  Dongbeom Song  ;  Hyo Suk Nam  ;  Young Dae Kim  ;  Ji Hoe Heo 
 STROKE, Vol.45(8) : 2305-2310, 2014 
Journal Title
Issue Date
Aged ; Ankle Brachial Index ; Blood Flow Velocity/physiology* ; Brachial Artery/physiopathology* ; Brain Ischemia/drug therapy ; Brain Ischemia/physiopathology* ; Female ; Fibrinolytic Agents/therapeutic use ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Pulse Wave Analysis* ; Retrospective Studies ; Stroke/drug therapy ; Stroke/physiopathology* ; Tissue Plasminogen Activator/therapeutic use ; Treatment Outcome
prognosis ; pulse wave analysis ; stroke
BACKGROUND AND PURPOSE: We investigated whether the brachial-ankle pulse wave velocity (baPWV) has prognostic value for predicting functional outcome after acute cerebral infarction and whether the prognostic value differs between stroke subtypes. METHODS: We included 1091 consecutive patients with first-ever acute cerebral infarction who underwent baPWV measurements. Stroke subtypes were classified using the Trial of Org 10172 in Acute Stroke Treatment classification. Poor functional outcomes were defined as modified Rankin Scale score >2 at 3 months after stroke onset. RESULTS: We noted that 181 (16.59%) patients had a poor functional outcome. In multivariate logistic regression, patients in the highest tertile of baPWV (>22.25 m/s) were found to be at increased risk for poor functional outcome (adjusted odds ratio, 1.88; 95% confidence interval, 1.06-3.40) compared with those in the lowest tertile (<17.55 m/s). No significant interaction between baPWV and stroke subtype was noted. Receiver operating characteristic curve analysis indicated that the addition of baPWV to the prediction model significantly improved the discrimination ability for poor functional outcome. CONCLUSIONS: baPWV has an independent prognostic value for predicting functional outcome after acute cerebral infarction. The prognostic value did not differ according to the stroke subtype.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Dae(김영대) ORCID logo https://orcid.org/0000-0001-5750-2616
Kim, Eun Hye(김은혜)
Kim, Jinkwon(김진권) ORCID logo https://orcid.org/0000-0003-0156-9736
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Song, Dong Beom(송동범)
Lee, Ki Jeong(이기정)
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
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