4 390

Cited 16 times in

The effect of platelet-rich plasma on composite graft survival.

 Yeo Reum Jeon  ;  Eun Hye Kang  ;  Chae Eun Yang  ;  In Sik Yun  ;  Won Jai Lee  ;  Dae Hyun Lew 
 PLASTIC AND RECONSTRUCTIVE SURGERY, Vol.134(2) : 239-246, 2014 
Journal Title
Issue Date
Animals ; Ear Cartilage/transplantation* ; Graft Survival* ; Outcome Assessment (Health Care) ; Platelet-Rich Plasma* ; Rabbits ; Random Allocation ; Skin Transplantation/methods* ; Transplantation, Autologous/methods
BACKGROUND: Composite grafts are suitable for facial reconstruction because of good color matching, low donor-site morbidity, acceptable texture, and easy surgical techniques. However, their use is limited to small defects and by unpredictable survival rates. As platelet-rich plasma contains large numbers of growth factors and has been widely used for tissue regeneration, this study aimed to investigate platelet-rich plasma as an adjuvant to enhance composite graft survival. METHODS:Twenty New Zealand White rabbits were used, and chondrocutaneous composite grafts were applied to their ears. The grafts were then returned to their original positions after rotation to block the original circulation from the base of the graft. Each of the individual ears was assigned randomly into one of two groups: experimental (n=20; platelet-rich plasma group) or control (n=20; control group). The surrounding skin of the composite graft was injected with either 1.0 ml of platelet-rich plasma derived from autologous whole blood in the platelet-rich plasma group or normal saline in the control group. Graft survival, cutaneous blood flow, CD31-stained vessels, and vascular endothelial growth factor protein levels were examined. RESULTS:Twelve days after surgery, graft viability in the platelet-rich plasma group was higher than in the control group. Blood perfusion was also higher in the platelet-rich plasma group. Compared with the control group, the number of CD31 blood vessels and vascular endothelial growth factor expression levels were significantly increased in the platelet-rich plasma group. CONCLUSIONS:The authors' results suggest that platelet-rich plasma restores the perfusion of composite grafts by enhancing revascularization and may exert therapeutic effects on the survival of composite grafts.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
Yonsei Authors
Kang, Eun Hye(강은혜)
Yang, Chae Eun(양채은) ORCID logo https://orcid.org/0000-0001-8128-791X
Lew, Dae Hyun(유대현)
Yun, In Sik(윤인식) ORCID logo https://orcid.org/0000-0003-1103-7047
Lee, Won Jai(이원재) ORCID logo https://orcid.org/0000-0003-3056-0503
Jeon, Yeo Reum(전여름)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.