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Cost-effectiveness of liver cancer screening in adults at high risk for liver cancer in the Republic of Korea.

Authors
 Young Hwa Lee  ;  Kui Son Choi  ;  Jae Kwan Jun  ;  Mina Suh  ;  Hoo-Yeon Lee  ;  Youn Nam Kim  ;  Chung Mo Nam  ;  Eun-Cheol Park  ;  Woo-Hyun Cho 
Citation
 CANCER RESEARCH AND TREATMENT, Vol.46(3) : 223-233, 2014 
Journal Title
 CANCER RESEARCH AND TREATMENT 
ISSN
 1598-2998 
Issue Date
2014
Keywords
Liver neoplasms ; Screening ; Cost-benefit analysis
Abstract
PURPOSE: This study was conducted in order to determine the most cost-effective strategy, in terms of interval and age range, forliver cancer screening in the high-risk population of Korea. MATERIALS AND METHODS: A stochastic modelwas used to simulate the cost-effectiveness ofliver cancer screening by combined ultrasonography and alpha-fetoprotein testing when varying both screening intervals and age ranges. The effectiveness of these screening strategies in the high-risk population was defined as the probability of detecting preclinical liver cancer, and costwas based on the direct cost ofthe screening and confirmative tests. Optimal cost-effectiveness was determined using the incremental cost-effectiveness ratio. RESULTS: Among the 36 alternative strategies, one-year or two-year interval screening for men aged between 50 and 80 years, six-month or one-year interval screening for men aged between 40 and 80 years, and six-month interval screening for men aged between 30 and 80 years were identified as non-dominated strategies. For women, identified non-dominated strategies were: one-year interval screening between age 50 and 65 years, one-year or six-month interval screening between age 50 and 80 years, six-month interval screening between age 40 and 80 years, and six-month interval screening between age 30 and 80 years. CONCLUSION: In Korea, a one-year screening interval for men aged 50 to 80 years would be marginally cost-effective. Further studies should be conducted in order to evaluate effectiveness of liver cancer screening, and compare the cost effectiveness of different liver cancer screening programs with a final outcome indicator such as qualityadjusted life-years or disability-adjusted life-years.
Files in This Item:
T201402141.pdf Download
DOI
10.4143/crt.2014.46.3.223
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
Yonsei Authors
Kim, Youn Nam(김윤남)
Nam, Jung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Park, Eun-Cheol(박은철) ORCID logo https://orcid.org/0000-0002-2306-5398
Cho, Woo Hyun(조우현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99160
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