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Cost-effectiveness of liver cancer screening in adults at high risk for liver cancer in the Republic of Korea.

DC Field Value Language
dc.contributor.author김윤남-
dc.contributor.author남정모-
dc.contributor.author박은철-
dc.contributor.author조우현-
dc.date.accessioned2015-01-06T16:59:26Z-
dc.date.available2015-01-06T16:59:26Z-
dc.date.issued2014-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99160-
dc.description.abstractPURPOSE: This study was conducted in order to determine the most cost-effective strategy, in terms of interval and age range, forliver cancer screening in the high-risk population of Korea. MATERIALS AND METHODS: A stochastic modelwas used to simulate the cost-effectiveness ofliver cancer screening by combined ultrasonography and alpha-fetoprotein testing when varying both screening intervals and age ranges. The effectiveness of these screening strategies in the high-risk population was defined as the probability of detecting preclinical liver cancer, and costwas based on the direct cost ofthe screening and confirmative tests. Optimal cost-effectiveness was determined using the incremental cost-effectiveness ratio. RESULTS: Among the 36 alternative strategies, one-year or two-year interval screening for men aged between 50 and 80 years, six-month or one-year interval screening for men aged between 40 and 80 years, and six-month interval screening for men aged between 30 and 80 years were identified as non-dominated strategies. For women, identified non-dominated strategies were: one-year interval screening between age 50 and 65 years, one-year or six-month interval screening between age 50 and 80 years, six-month interval screening between age 40 and 80 years, and six-month interval screening between age 30 and 80 years. CONCLUSION: In Korea, a one-year screening interval for men aged 50 to 80 years would be marginally cost-effective. Further studies should be conducted in order to evaluate effectiveness of liver cancer screening, and compare the cost effectiveness of different liver cancer screening programs with a final outcome indicator such as qualityadjusted life-years or disability-adjusted life-years.-
dc.description.statementOfResponsibilityopen-
dc.format.extent223~233-
dc.relation.isPartOfCANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleCost-effectiveness of liver cancer screening in adults at high risk for liver cancer in the Republic of Korea.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine (예방의학)-
dc.contributor.googleauthorYoung Hwa Lee-
dc.contributor.googleauthorKui Son Choi-
dc.contributor.googleauthorJae Kwan Jun-
dc.contributor.googleauthorMina Suh-
dc.contributor.googleauthorHoo-Yeon Lee-
dc.contributor.googleauthorYoun Nam Kim-
dc.contributor.googleauthorChung Mo Nam-
dc.contributor.googleauthorEun-Cheol Park-
dc.contributor.googleauthorWoo-Hyun Cho-
dc.identifier.doi10.4143/crt.2014.46.3.223-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01264-
dc.contributor.localIdA03869-
dc.contributor.localIdA01618-
dc.contributor.localIdA04535-
dc.relation.journalcodeJ00453-
dc.identifier.eissn2005-9256-
dc.identifier.pmid25038757-
dc.subject.keywordLiver neoplasms-
dc.subject.keywordScreening-
dc.subject.keywordCost-benefit analysis-
dc.contributor.alternativeNameKim, Youn Nam-
dc.contributor.alternativeNameNam, Jung Mo-
dc.contributor.alternativeNamePark, Eun Chul-
dc.contributor.alternativeNameCho, Woo Hyun-
dc.contributor.affiliatedAuthorNam, Jung Mo-
dc.contributor.affiliatedAuthorCho, Woo Hyun-
dc.contributor.affiliatedAuthorPark, Eun Chul-
dc.contributor.affiliatedAuthorKim, Youn Nam-
dc.citation.volume46-
dc.citation.number3-
dc.citation.startPage223-
dc.citation.endPage233-
dc.identifier.bibliographicCitationCANCER RESEARCH AND TREATMENT, Vol.46(3) : 223-233, 2014-
dc.identifier.rimsid51187-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

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