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Effect of Dexmedetomidine on the Corrected QT and Tp-e Intervals during Spinal Anesthesia

Authors
 Youngsoon Kim  ;  So Yeon Kim  ;  Jong Seok Lee  ;  Hee Jung Kong  ;  Dong Woo Han 
Citation
 YONSEI MEDICAL JOURNAL, Vol.55(2) : 517-522, 2014 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2014
MeSH
Adult ; Anesthesia, Spinal/adverse effects* ; Blood Pressure/drug effects ; Dexmedetomidine/therapeutic use* ; Electrocardiography ; Female ; Heart Rate/drug effects ; Humans ; Hypnotics and Sedatives/therapeutic use ; Long QT Syndrome/chemically induced ; Long QT Syndrome/drug therapy* ; Male ; Middle Aged ; Reference Values ; Young Adult ; s
Keywords
Dexmedetomidine ; electrocardiogram ; spinal anesthesia
Abstract
PURPOSE: The aim of this study is to evaluate the effect of dexmedetomidine on corrected QT (QTc) and Tp-e intervals in patients undergoing spinal anesthesia. MATERIALS AND METHODS: We studied 50 patients who were scheduled to undergo spinal anesthesia before orthopedic surgeries. Patients were allocated to receive either an infusion of dexmedetomidine or normal saline after spinal anesthesia. RESULTS: QTc intervals were significantly prolonged after spinal anesthesia, and the prolonged QTc interval returned to baseline values 10 minutes after either normal saline or dexmedetomidine administration in both groups. The QTc interval values after dexmedetomidine administration were significantly shorter compared to the QTc interval values just before dexmedetomidine administration. CONCLUSION: Dexmedetomidine could promote the return of a prolonged QTc interval induced by spinal anesthesia and might be helpful in patients who have a prolonged QTc interval.
Files in This Item:
T201402071.pdf Download
DOI
10.3349/ymj.2014.55.2.517
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kim, So Yeon(김소연) ORCID logo https://orcid.org/0000-0001-5352-157X
Kim, Young Soon(김영순)
Lee, Jong Seok(이종석) ORCID logo https://orcid.org/0000-0002-7945-2530
Han, Dong Woo(한동우) ORCID logo https://orcid.org/0000-0002-8757-663X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99113
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