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Delta Neutrophil Index as a Prognostic Marker of Early Mortality in Gram Negative Bacteremia

Authors
 Hye Won Kim  ;  Ji Hyun Yoon  ;  Sung Joon Jin  ;  Sun Bean Kim  ;  Nam Su Ku  ;  Su Jin Jeong  ;  Sang Hoon Han  ;  Jun Yong Choi  ;  June Myung Kim  ;  Young Goo Song 
Citation
 Infection and Chemotherapy, Vol.46(2) : 94-102, 2014 
Journal Title
 Infection and Chemotherapy 
ISSN
 2093-2340 
Issue Date
2014
Keywords
Bacteremia ; Biological markers ; Gram-negative bacterial infections ; Mortality ; Prognosis
Abstract
BACKGROUND: Sepsis is a syndrome that results in high morbidity and mortality. We investigated the delta neutrophil index (DN) as a predictive marker of early mortality in patients with gram-negative bacteremia. MATERIALS AND METHODS: We conducted a retrospective study at a tertiary referral hospital in South Korea from November 2010 to March 2011. The DN was measured at onset of bacteremia and 24 hours and 72 hours later. The DN was calculated using an automatic hematology analyzer. Factors associated with 10-day mortality were assessed using logistic regression. RESULTS: A total of 172 patients with gram-negative bacteremia were included in the analysis; of these, 17 patients died within 10 days of bacteremia onset. In multivariate analysis, Sequental organ failure assessment scores (odds ratio [OR]: 2.24, 95% confidence interval [CI]: 1.31 to 3.84; P = 0.003), DN-day 1 ≥ 7.6% (OR: 305.18, 95% CI: 1.73 to 53983.52; P = 0.030) and DN-day 3 ≥ DN-day 1 (OR: 77.77, 95% CI: 1.90 to 3188.05; P = 0.022) were independent factors associated with early mortality in gram-negative bacteremia. Of four multivariate models developed and tested using various factors, the model using both DN-day 1 ≥ 7.6% and DN-day 3 ≥ DN-day 1 was most predictive early mortality. CONCLUSIONS: DN may be a useful marker of early mortality in patients with gram-negative bacteremia. We found both DN-day 1 and DN trend to be significantly associated with early mortality.
Files in This Item:
T201401917.pdf Download
DOI
10.3947/ic.2014.46.2.94
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, Sun Bean(김선빈)
Kim, June Myung(김준명)
Kim, Hye Won(김혜원)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Yoon, Ji Hyun(윤지현)
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Jin, Sung Joon(진성준)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99024
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