342 690

Cited 20 times in

Delta Neutrophil Index as a Prognostic Marker of Early Mortality in Gram Negative Bacteremia

DC Field Value Language
dc.contributor.author구남수-
dc.contributor.author김선빈-
dc.contributor.author김준명-
dc.contributor.author김혜원-
dc.contributor.author송영구-
dc.contributor.author윤지현-
dc.contributor.author정수진-
dc.contributor.author진성준-
dc.contributor.author최준용-
dc.contributor.author한상훈-
dc.date.accessioned2015-01-06T16:55:11Z-
dc.date.available2015-01-06T16:55:11Z-
dc.date.issued2014-
dc.identifier.issn2093-2340-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99024-
dc.description.abstractBACKGROUND: Sepsis is a syndrome that results in high morbidity and mortality. We investigated the delta neutrophil index (DN) as a predictive marker of early mortality in patients with gram-negative bacteremia. MATERIALS AND METHODS: We conducted a retrospective study at a tertiary referral hospital in South Korea from November 2010 to March 2011. The DN was measured at onset of bacteremia and 24 hours and 72 hours later. The DN was calculated using an automatic hematology analyzer. Factors associated with 10-day mortality were assessed using logistic regression. RESULTS: A total of 172 patients with gram-negative bacteremia were included in the analysis; of these, 17 patients died within 10 days of bacteremia onset. In multivariate analysis, Sequental organ failure assessment scores (odds ratio [OR]: 2.24, 95% confidence interval [CI]: 1.31 to 3.84; P = 0.003), DN-day 1 ≥ 7.6% (OR: 305.18, 95% CI: 1.73 to 53983.52; P = 0.030) and DN-day 3 ≥ DN-day 1 (OR: 77.77, 95% CI: 1.90 to 3188.05; P = 0.022) were independent factors associated with early mortality in gram-negative bacteremia. Of four multivariate models developed and tested using various factors, the model using both DN-day 1 ≥ 7.6% and DN-day 3 ≥ DN-day 1 was most predictive early mortality. CONCLUSIONS: DN may be a useful marker of early mortality in patients with gram-negative bacteremia. We found both DN-day 1 and DN trend to be significantly associated with early mortality.-
dc.description.statementOfResponsibilityopen-
dc.format.extent94~102-
dc.relation.isPartOfINFECTION AND CHEMOTHERAPY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleDelta Neutrophil Index as a Prognostic Marker of Early Mortality in Gram Negative Bacteremia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHye Won Kim-
dc.contributor.googleauthorJi Hyun Yoon-
dc.contributor.googleauthorSung Joon Jin-
dc.contributor.googleauthorSun Bean Kim-
dc.contributor.googleauthorNam Su Ku-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorJune Myung Kim-
dc.contributor.googleauthorYoung Goo Song-
dc.identifier.doi10.3947/ic.2014.46.2.94-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00189-
dc.contributor.localIdA00547-
dc.contributor.localIdA00953-
dc.contributor.localIdA01176-
dc.contributor.localIdA02037-
dc.contributor.localIdA02609-
dc.contributor.localIdA03638-
dc.contributor.localIdA03983-
dc.contributor.localIdA04191-
dc.contributor.localIdA04286-
dc.relation.journalcodeJ01053-
dc.identifier.eissn2092-6448-
dc.identifier.pmid25024871-
dc.subject.keywordBacteremia-
dc.subject.keywordBiological markers-
dc.subject.keywordGram-negative bacterial infections-
dc.subject.keywordMortality-
dc.subject.keywordPrognosis-
dc.contributor.alternativeNameKu, Nam Su-
dc.contributor.alternativeNameKim, Sun Bean-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameKim, Hye Won-
dc.contributor.alternativeNameSong, Young Goo-
dc.contributor.alternativeNameYoon, Ji Hyun-
dc.contributor.alternativeNameJeong, Su Jin-
dc.contributor.alternativeNameJin, Sung Joon-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.affiliatedAuthorKu, Nam Su-
dc.contributor.affiliatedAuthorKim, Sun Bean-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorKim, Hye Won-
dc.contributor.affiliatedAuthorSong, Young Goo-
dc.contributor.affiliatedAuthorYoon, Ji Hyun-
dc.contributor.affiliatedAuthorJeong, Su Jin-
dc.contributor.affiliatedAuthorJin, Sung Joon-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.citation.volume46-
dc.citation.number2-
dc.citation.startPage94-
dc.citation.endPage102-
dc.identifier.bibliographicCitationINFECTION AND CHEMOTHERAPY, Vol.46(2) : 94-102, 2014-
dc.identifier.rimsid50218-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.