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Association between Serum 25-Hydroxyvitamin D Level and Insulin Resistance in a Rural Population

 Bo Mi Song  ;  Hyeon Chang Kim  ;  Dong Phil Choi  ;  Sun Min Oh  ;  Il Suh 
 YONSEI MEDICAL JOURNAL, Vol.55(4) : 1036-1041, 2014 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group ; Cross-Sectional Studies ; Female ; Humans ; Insulin Resistance/physiology* ; Male ; Middle Aged ; Rural Population ; Vitamin D/analogs & derivatives* ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/epidemiology
Vitamin D ; epidemiology ; insulin resistance
PURPOSE: A low serum 25-hydroxyvitamin D [25(OH)D] level in the blood has been correlated with an increased risk of diabetes mellitus; however, the association between serum 25(OH)D level and insulin resistance has not been established in a Korean rural population. The aim of this study was to investigate the independent association between serum 25(OH)D level and insulin resistance in rural Korean adults. MATERIALS AND METHODS: This study used data from the Korean Genome Epidemiology Study-Kangwha Study. In the 2011 study, 1200 adults completed health examinations. In an ancillary study, serum 25(OH)D level was measured in a subsample (n=813). After excluding those taking vitamin D supplements, a cross-sectional analysis was carried out on 807 participants (324 men and 483 women) aged 40 to 89 years old. Measured from overnight fasting blood samples, glucose and insulin levels were used to calculate the homeostasis model assessment for insulin resistance (HOMA-IR). Measures of glucose, insulin, and HOMA-IR were log-transformed for parametric tests. RESULTS: Serum 25(OH)D level was inversely associated with HOMA-IR (β=-0.003, p=0.039) in a univariate analysis. However, the association was not significant after adjustment for sex and age (β=-0.002, p=0.123) or after adjustment for sex, age, body mass index, smoking status, alcohol intake, and regular exercise (β=-0.003, p=0.247). CONCLUSION: Our findings suggest that vitamin D is not independently associated with insulin resistance in Korean men and women.
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1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Suh, Il(서일) ORCID logo https://orcid.org/0000-0002-9689-7849
Oh, Sun Min(오선민)
Choi, Dong Phil(최동필)
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