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Association between Serum 25-Hydroxyvitamin D Level and Insulin Resistance in a Rural Population

DC FieldValueLanguage
dc.contributor.author서일-
dc.contributor.author오선민-
dc.contributor.author최동필-
dc.contributor.author김현창-
dc.date.accessioned2015-01-06T16:53:47Z-
dc.date.available2015-01-06T16:53:47Z-
dc.date.issued2014-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98978-
dc.description.abstractPURPOSE: A low serum 25-hydroxyvitamin D [25(OH)D] level in the blood has been correlated with an increased risk of diabetes mellitus; however, the association between serum 25(OH)D level and insulin resistance has not been established in a Korean rural population. The aim of this study was to investigate the independent association between serum 25(OH)D level and insulin resistance in rural Korean adults. MATERIALS AND METHODS: This study used data from the Korean Genome Epidemiology Study-Kangwha Study. In the 2011 study, 1200 adults completed health examinations. In an ancillary study, serum 25(OH)D level was measured in a subsample (n=813). After excluding those taking vitamin D supplements, a cross-sectional analysis was carried out on 807 participants (324 men and 483 women) aged 40 to 89 years old. Measured from overnight fasting blood samples, glucose and insulin levels were used to calculate the homeostasis model assessment for insulin resistance (HOMA-IR). Measures of glucose, insulin, and HOMA-IR were log-transformed for parametric tests. RESULTS: Serum 25(OH)D level was inversely associated with HOMA-IR (β=-0.003, p=0.039) in a univariate analysis. However, the association was not significant after adjustment for sex and age (β=-0.002, p=0.123) or after adjustment for sex, age, body mass index, smoking status, alcohol intake, and regular exercise (β=-0.003, p=0.247). CONCLUSION: Our findings suggest that vitamin D is not independently associated with insulin resistance in Korean men and women.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1036~1041-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAsian Continental Ancestry Group-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInsulin Resistance/physiology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRural Population-
dc.subject.MESHVitamin D/analogs & derivatives*-
dc.subject.MESHVitamin D/blood-
dc.subject.MESHVitamin D Deficiency/blood-
dc.subject.MESHVitamin D Deficiency/epidemiology-
dc.titleAssociation between Serum 25-Hydroxyvitamin D Level and Insulin Resistance in a Rural Population-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine (예방의학)-
dc.contributor.googleauthorBo Mi Song-
dc.contributor.googleauthorHyeon Chang Kim-
dc.contributor.googleauthorDong Phil Choi-
dc.contributor.googleauthorSun Min Oh-
dc.contributor.googleauthorIl Suh-
dc.identifier.doi10.3349/ymj.2014.55.4.1036-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04051-
dc.contributor.localIdA01899-
dc.contributor.localIdA02373-
dc.contributor.localIdA01142-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid24954334-
dc.subject.keywordVitamin D-
dc.subject.keywordepidemiology-
dc.subject.keywordinsulin resistance-
dc.contributor.alternativeNameSuh, Il-
dc.contributor.alternativeNameOh, Sun Min-
dc.contributor.alternativeNameChoi, Dong Phil-
dc.contributor.alternativeNameKim, Hyeon Chang-
dc.contributor.affiliatedAuthorChoi, Dong Phil-
dc.contributor.affiliatedAuthorSuh, Il-
dc.contributor.affiliatedAuthorOh, Sun Min-
dc.contributor.affiliatedAuthorKim, Hyeon Chang-
dc.citation.volume55-
dc.citation.number4-
dc.citation.startPage1036-
dc.citation.endPage1041-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.55(4) : 1036-1041, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers

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