Cited 11 times in
Effect of voriconazole and ultraviolet - A combination therapy compared to voriconazole single treatment on fusarium solani fungal keratitis
DC Field | Value | Language |
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dc.contributor.author | 김은도 | - |
dc.contributor.author | 서경률 | - |
dc.contributor.author | 윤상철 | - |
dc.contributor.author | 임형택 | - |
dc.contributor.author | 한수정 | - |
dc.date.accessioned | 2015-01-06T16:53:31Z | - |
dc.date.available | 2015-01-06T16:53:31Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1080-7683 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98969 | - |
dc.description.abstract | Purpose: To demonstrate that ultraviolet-A (UV-A) and voriconazole combination therapy is more effective than voriconazole single treatment for fungal keratitis. Methods: The in vitro UV-A (375 nm) fungicidal effect was evaluated on Fusarium solani solutions. Each fungal solution was irradiated with different UV-A irradiation doses. Also, a fungal solution containing voriconazole was also irradiated with UV-A. The in vivo therapeutic effect of UV-A and voriconazole treatment was studied in a rabbit keratitis model. Fungi were injected intrastromally into the cornea of 16 rabbits. Each treatment was initiated 3 days after fungal injection and continued up to 8 days for the following groups: Group 1, control; Group 2, treated with UV-A once a day; Group 3, treated with voriconazole 3 times a day; Group 4, treated with voriconazole 3 times a day and UV-A once a day. On the last day, the sclera–cornea buttons were extracted and microbiological and histological evaluations were performed. Results: The colony-forming units (CFUs) of fungal solutions in culture significantly decreased with UV-A irradiation. The CFUs of fungal solutions containing voriconazole also decreased with UV-A irradiation. In vivo, clinical scores of Group 3 (P=0.03) and Group 4 (P=0.02) 5 days after treatment were significantly lower compared to that of Group 1. The clinical score of Group 4 (P=0.03) 5 days after treatment was significantly lower compared to that of Group 3. The histopathological scores 5 days after treatment were significantly lower in Group 4 compared to those of Group 1 (P<0.01) and Group 3 (P=0.02). Based on our CFU analysis, only Group 4 showed significantly lower CFUs compared to Group 1 (P=0.04). Conclusions: UV-A and voriconazole combination treatment could be a safe and effective alternative to voriconazole single treatment for fungal keratitis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 381~386 | - |
dc.relation.isPartOf | JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antifungal Agents/administration & dosage | - |
dc.subject.MESH | Combined Modality Therapy/methods | - |
dc.subject.MESH | Eye Infections, Fungal/pathology | - |
dc.subject.MESH | Eye Infections, Fungal/therapy* | - |
dc.subject.MESH | Fusariosis/pathology | - |
dc.subject.MESH | Fusariosis/therapy* | - |
dc.subject.MESH | Fusarium/drug effects | - |
dc.subject.MESH | Fusarium/isolation & purification* | - |
dc.subject.MESH | Fusarium/radiation effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Keratitis/pathology | - |
dc.subject.MESH | Keratitis/therapy* | - |
dc.subject.MESH | Rabbits | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Ultraviolet Therapy/methods* | - |
dc.subject.MESH | Voriconazole/administration & dosage* | - |
dc.title | Effect of voriconazole and ultraviolet - A combination therapy compared to voriconazole single treatment on fusarium solani fungal keratitis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Choi Kyoung Sub | - |
dc.contributor.googleauthor | Yoon Sang Chul | - |
dc.contributor.googleauthor | Rim Tyler Hyung Taek | - |
dc.contributor.googleauthor | Han Soo Jung | - |
dc.contributor.googleauthor | Kim Eun-Do | - |
dc.contributor.googleauthor | Seo Kyoung Yul | - |
dc.identifier.doi | 10.1089/jop.2013.0167 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00802 | - |
dc.contributor.localId | A01870 | - |
dc.contributor.localId | A02560 | - |
dc.contributor.localId | A03419 | - |
dc.contributor.localId | A04295 | - |
dc.relation.journalcode | J01654 | - |
dc.identifier.eissn | 1557-7732 | - |
dc.identifier.pmid | 24724576 | - |
dc.identifier.url | http://online.liebertpub.com/doi/abs/10.1089/jop.2013.0167 | - |
dc.contributor.alternativeName | Kim, Eun Do | - |
dc.contributor.alternativeName | Seo, Kyuong Yul | - |
dc.contributor.alternativeName | Yoon, Sang Chul | - |
dc.contributor.alternativeName | Rim, Tyler H. T. | - |
dc.contributor.alternativeName | Han, Soo Jung | - |
dc.contributor.affiliatedAuthor | Kim, Eun Do | - |
dc.contributor.affiliatedAuthor | Seo, Kyuong Yul | - |
dc.contributor.affiliatedAuthor | Yoon, Sang Chul | - |
dc.contributor.affiliatedAuthor | Rim, Tyler Hyungtaek | - |
dc.contributor.affiliatedAuthor | Han, Soo Jung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 30 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 381 | - |
dc.citation.endPage | 386 | - |
dc.identifier.bibliographicCitation | JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, Vol.30(5) : 381-386, 2014 | - |
dc.identifier.rimsid | 54316 | - |
dc.type.rims | ART | - |
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