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Effect of voriconazole and ultraviolet - A combination therapy compared to voriconazole single treatment on fusarium solani fungal keratitis

DC FieldValueLanguage
dc.contributor.author김은도-
dc.contributor.author서경률-
dc.contributor.author윤상철-
dc.contributor.author임형택-
dc.contributor.author한수정-
dc.date.accessioned2015-01-06T16:53:31Z-
dc.date.available2015-01-06T16:53:31Z-
dc.date.issued2014-
dc.identifier.issn1080-7683-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98969-
dc.description.abstractPurpose: To demonstrate that ultraviolet-A (UV-A) and voriconazole combination therapy is more effective than voriconazole single treatment for fungal keratitis. Methods: The in vitro UV-A (375 nm) fungicidal effect was evaluated on Fusarium solani solutions. Each fungal solution was irradiated with different UV-A irradiation doses. Also, a fungal solution containing voriconazole was also irradiated with UV-A. The in vivo therapeutic effect of UV-A and voriconazole treatment was studied in a rabbit keratitis model. Fungi were injected intrastromally into the cornea of 16 rabbits. Each treatment was initiated 3 days after fungal injection and continued up to 8 days for the following groups: Group 1, control; Group 2, treated with UV-A once a day; Group 3, treated with voriconazole 3 times a day; Group 4, treated with voriconazole 3 times a day and UV-A once a day. On the last day, the sclera–cornea buttons were extracted and microbiological and histological evaluations were performed. Results: The colony-forming units (CFUs) of fungal solutions in culture significantly decreased with UV-A irradiation. The CFUs of fungal solutions containing voriconazole also decreased with UV-A irradiation. In vivo, clinical scores of Group 3 (P=0.03) and Group 4 (P=0.02) 5 days after treatment were significantly lower compared to that of Group 1. The clinical score of Group 4 (P=0.03) 5 days after treatment was significantly lower compared to that of Group 3. The histopathological scores 5 days after treatment were significantly lower in Group 4 compared to those of Group 1 (P<0.01) and Group 3 (P=0.02). Based on our CFU analysis, only Group 4 showed significantly lower CFUs compared to Group 1 (P=0.04). Conclusions: UV-A and voriconazole combination treatment could be a safe and effective alternative to voriconazole single treatment for fungal keratitis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent381~386-
dc.relation.isPartOfJOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAntifungal Agents/administration & dosage-
dc.subject.MESHCombined Modality Therapy/methods-
dc.subject.MESHEye Infections, Fungal/pathology-
dc.subject.MESHEye Infections, Fungal/therapy*-
dc.subject.MESHFusariosis/pathology-
dc.subject.MESHFusariosis/therapy*-
dc.subject.MESHFusarium/drug effects-
dc.subject.MESHFusarium/isolation & purification*-
dc.subject.MESHFusarium/radiation effects-
dc.subject.MESHHumans-
dc.subject.MESHKeratitis/pathology-
dc.subject.MESHKeratitis/therapy*-
dc.subject.MESHRabbits-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHUltraviolet Therapy/methods*-
dc.subject.MESHVoriconazole/administration & dosage*-
dc.titleEffect of voriconazole and ultraviolet - A combination therapy compared to voriconazole single treatment on fusarium solani fungal keratitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorChoi Kyoung Sub-
dc.contributor.googleauthorYoon Sang Chul-
dc.contributor.googleauthorRim Tyler Hyung Taek-
dc.contributor.googleauthorHan Soo Jung-
dc.contributor.googleauthorKim Eun-Do-
dc.contributor.googleauthorSeo Kyoung Yul-
dc.identifier.doi10.1089/jop.2013.0167-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00802-
dc.contributor.localIdA01870-
dc.contributor.localIdA02560-
dc.contributor.localIdA03419-
dc.contributor.localIdA04295-
dc.relation.journalcodeJ01654-
dc.identifier.eissn1557-7732-
dc.identifier.pmid24724576-
dc.identifier.urlhttp://online.liebertpub.com/doi/abs/10.1089/jop.2013.0167-
dc.contributor.alternativeNameKim, Eun Do-
dc.contributor.alternativeNameSeo, Kyuong Yul-
dc.contributor.alternativeNameYoon, Sang Chul-
dc.contributor.alternativeNameRim, Tyler H. T.-
dc.contributor.alternativeNameHan, Soo Jung-
dc.contributor.affiliatedAuthorKim, Eun Do-
dc.contributor.affiliatedAuthorSeo, Kyuong Yul-
dc.contributor.affiliatedAuthorYoon, Sang Chul-
dc.contributor.affiliatedAuthorRim, Tyler Hyungtaek-
dc.contributor.affiliatedAuthorHan, Soo Jung-
dc.rights.accessRightsfree-
dc.citation.volume30-
dc.citation.number5-
dc.citation.startPage381-
dc.citation.endPage386-
dc.identifier.bibliographicCitationJOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, Vol.30(5) : 381-386, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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