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Role of calcium signaling in epithelial bicarbonate secretion

Authors
 Jinsei Jung  ;  Min Goo Lee 
Citation
 Cell Calcium, Vol.55(6) : 376-384, 2014 
Journal Title
 Cell Calcium 
ISSN
 0143-4160 
Issue Date
2014
Abstract
Transepithelial bicarbonate secretion plays a key role in the maintenance of fluid and protein secretion from epithelial cells and the protection of the epithelial cell surface from various pathogens. Epithelial bicarbonate secretion is mainly under the control of cAMP and calcium signaling. While the physiological roles and molecular mechanisms of cAMP-induced bicarbonate secretion are relatively well defined, those induced by calcium signaling remain poorly understood in most epithelia. The present review summarizes the current status of knowledge on the role of calcium signaling in epithelial bicarbonate secretion. Specifically, this review introduces how cytosolic calcium signaling can increase bicarbonate secretion by regulating membrane transport proteins and how it synergizes with cAMP-induced mechanisms in epithelial cells. In addition, tissue-specific variations in the pancreas, salivary glands, intestines, bile ducts, and airways are discussed. We hope that the present report will stimulate further research into this important topic. These studies will provide the basis for future medicines for a wide spectrum of epithelial disorders including cystic fibrosis, Sjögren's syndrome, and chronic pancreatitis.
Full Text
http://www.sciencedirect.com/science/article/pii/S0143416014000244
DOI
10.1016/j.ceca.2014.02.002
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
이민구(Lee, Min Goo) ORCID logo https://orcid.org/0000-0001-7436-012X
정진세(Jung, Jinsei) ORCID logo https://orcid.org/0000-0003-1906-6969
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98943
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