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Hierarchical cluster analysis of progression patterns in open-angle glaucoma patients with medical treatment

Authors
 Hyoung Won Bae  ;  Seungsoo Rho  ;  Hye Sun Lee  ;  Naeun Lee  ;  Samin Hong  ;  Gong Je Seong  ;  Kyung Rim Sung  ;  Chan Yun Kim 
Citation
 INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol.55(5) : 3231-3236, 2014 
Journal Title
 INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 
ISSN
 0146-0404 
Issue Date
2014
MeSH
Adult ; Aged ; Antihypertensive Agents/administration & dosage* ; Cluster Analysis ; Disease Progression ; Female ; Follow-Up Studies ; Glaucoma, Open-Angle/diagnosis* ; Glaucoma, Open-Angle/drug therapy ; Humans ; Intraocular Pressure* ; Male ; Middle Aged ; Ophthalmic Solutions ; Retrospective Studies ; Visual Field Tests ; Visual Fields*
Keywords
hierarchical cluster analysis ; open-angle glaucoma ; progression
Abstract
PURPOSE: To classify medically treated open-angle glaucoma (OAG) by the pattern of progression using hierarchical cluster analysis, and to determine OAG progression characteristics by comparing clusters. METHODS: Ninety-five eyes of 95 OAG patients who received medical treatment, and who had undergone visual field (VF) testing at least once per year for 5 or more years. OAG was classified into subgroups using hierarchical cluster analysis based on the following five variables: baseline mean deviation (MD), baseline visual field index (VFI), MD slope, VFI slope, and Glaucoma Progression Analysis (GPA) printout. After that, other parameters were compared between clusters. RESULTS: Two clusters were made after a hierarchical cluster analysis. Cluster 1 showed -4.06 ± 2.43 dB baseline MD, 92.58% ± 6.27% baseline VFI, -0.28 ± 0.38 dB per year MD slope, -0.52% ± 0.81% per year VFI slope, and all "no progression" cases in GPA printout, whereas cluster 2 showed -8.68 ± 3.81 baseline MD, 77.54 ± 12.98 baseline VFI, -0.72 ± 0.55 MD slope, -2.22 ± 1.89 VFI slope, and seven "possible" and four "likely" progression cases in GPA printout. There were no significant differences in age, sex, mean IOP, central corneal thickness, and axial length between clusters. However, cluster 2 included more high-tension glaucoma patients and used a greater number of antiglaucoma eye drops significantly compared with cluster 1. CONCLUSIONS: Hierarchical cluster analysis of progression patterns divided OAG into slow and fast progression groups, evidenced by assessing the parameters of glaucomatous progression in VF testing. In the fast progression group, the prevalence of high-tension glaucoma was greater and the number of antiglaucoma medications administered was increased versus the slow progression group.
Full Text
http://www.iovs.org/content/55/5/3231.long
DOI
10.1167/iovs.13-13856
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Bae, Hyoung Won(배형원) ORCID logo https://orcid.org/0000-0002-8421-5636
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Lee, Na Eun(이나은)
Hong, Sa Min(홍사민)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98884
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