164 394

Cited 8 times in

Soluble CD93 Levels in Patients with Acute Myocardial Infarction and Its Implication on Clinical Outcome

Authors
 Jong-Chan Youn  ;  Hee Tae Yu  ;  Jae-Won Jeon  ;  Hye Sun Lee  ;  Yangsoo Jang  ;  Young Woo Park  ;  Yong-Beom Park  ;  Eui-Cheol Shin  ;  Jong-Won Ha 
Citation
 PLOS ONE, Vol.9(5) : e96538, 2014 
Journal Title
PLOS ONE
Issue Date
2014
MeSH
Acute Disease ; Biomarkers/blood ; Case-Control Studies ; Female ; Humans ; Inflammation/blood ; Inflammation/pathology ; Male ; Membrane Glycoproteins/blood* ; Middle Aged ; Myocardial Infarction/blood* ; Myocardial Infarction/pathology* ; Receptors, Complement/blood* ; Ventricular Dysfunction, Left/pathology
Abstract
BACKGROUND:
Inflammation plays a key role in the pathogenesis of acute myocardial infarction (MI). However, it is unclear whether marker of immune activation will provide prognostic information in these patients. We hypothesized that circulating levels of soluble CD93 (sCD93), a soluble form of transmembrane glycoprotein CD93, is increased in acute MI patients and its level would be associated with clinical outcomes in patients with acute MI.
METHODS:
We measured circulating levels of sCD93 in 120 patients with acute MI (63±13 yrs, M∶F = 85∶35) and in 120 age, sex-matched control subjects. In patients with acute MI, clinical characteristics, echocardiographic and laboratory findings were assessed at the time of initial enrollment. The primary outcome was defined as all-cause and cardiovascular death.
RESULTS:
Circulating sCD93 levels were significantly higher in patients with acute MI than in control subjects (552.1±293.7 vs. 429.8±114.2 ng/mL, p<0.0001). Upon in vitro inflammatory stimulation, increased CD93 shedding was demonstrated in acute MI patients but not in control subjects. During follow up period (median 208 days, 3-1058 days), the primary outcome occurred in 18 (15%) patients (9 cardiovascular deaths). Circulating levels of sCD93 were associated with all cause (p<0.0001) and cardiovascular (p<0.0001) mortality in patients with acute MI. Multivariate Cox regression analysis revealed that initial sCD93 level was found to be an independent predictor of all cause (p = 0.002) and cardiovascular mortality (p = 0.033) when controlled for age and left ventricular ejection fraction.
CONCLUSIONS:
Circulating levels of sCD93 are elevated in patients with acute MI and their levels were associated with adverse clinical outcomes
Files in This Item:
T201401343.pdf Download
DOI
10.1371/journal.pone.0096538
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Park, Yong Beom(박용범)
Yu, Hee Tae(유희태) ORCID logo https://orcid.org/0000-0002-6835-4759
Youn, Jong Chan(윤종찬)
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98708
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links