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Association between risk factors for vascular dementia and adiponectin

Authors
 Juhyun Song  ;  Won Taek Lee  ;  Kyung Ah Park  ;  Jong Eun Lee 
Citation
 BIOMED RESEARCH INTERNATIONAL, Vol.2014 : 261672, 2014 
Journal Title
 BIOMED RESEARCH INTERNATIONAL 
ISSN
 2314-6133 
Issue Date
2014
MeSH
Adiponectin/blood* ; Biomarkers/blood ; Comorbidity ; Dementia, Vascular/blood* ; Dementia, Vascular/diagnosis ; Dementia, Vascular/mortality* ; Diabetes Complications/blood* ; Diabetes Complications/diagnosis ; Diabetes Complications/mortality* ; Humans ; Prevalence ; Risk Assessment ; Stroke/blood* ; Stroke/diagnosis ; Stroke/mortality* ; Survival Rate
Abstract
Vascular dementia is caused by various factors, including increased age, diabetes, hypertension, atherosclerosis, and stroke. Adiponectin is an adipokine secreted by adipose tissue. Adiponectin is widely known as a regulating factor related to cardiovascular disease and diabetes. Adiponectin plasma levels decrease with age. Decreased adiponectin increases the risk of cardiovascular disease and diabetes. Adiponectin improves hypertension and atherosclerosis by acting as a vasodilator and antiatherogenic factor. Moreover, adiponectin is involved in cognitive dysfunction via modulation of insulin signal transduction in the brain. Case-control studies demonstrate the association between low adiponectin and increased risk of stroke, hypertension, and diabetes. This review summarizes the recent findings on the association between risk factors for vascular dementia and adiponectin. To emphasize this relationship, we will discuss the importance of research regarding the role of adiponectin in vascular dementia.
Files in This Item:
T201401309.pdf Download
DOI
10.1155/2014/261672
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Park, Kyung Ah(박경아)
Song, Ju Hyun(송주현)
Lee, Won Taek(이원택) ORCID logo https://orcid.org/0000-0001-7348-9562
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98679
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