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Stromal transforming growth factor-beta 1 is crucial for reinforcing the invasive potential of low invasive cancer

Authors
 Young Sun Hwang  ;  Kwang-Kyun Park  ;  Won-Yoon Chung 
Citation
 Archives of Oral Biology, Vol.59(7) : 687-694, 2014 
Journal Title
 Archives of Oral Biology 
ISSN
 0003-9969 
Issue Date
2014
Abstract
OBJECTIVE: Tumour cells alter the characteristics of the adjacent stroma to create a supportive microenvironment during cancer progression. In vitro and in vivo experiments were carried out to verify the role of stromal TGF-β1 in reinforcing of the invasive potential in low invasive cancer. MATERIALS AND METHODS: Isolated NF or CAF was co-cultured with low invasive HSC-2 cells to evaluate whether stromal TGF-β1 induced PDPN expression by Transwell invasion and influenced tumour growth in orthotopic xenografts. RESULTS: Stimulation by TGF-β1 promoted PDPN expression and Transwell invasion through SMAD signalling as well as activation of Src, P38 mitogen activated protein kinase and extracellular regulated kinase 1/2. PDPN induction was TβRII-dependent. Tumour growth of HSC-2 OSCC in a mouse xenograft was intensified in the tumour CAF microenvironment. CONCLUSIONS: Stromal TGF-β1 signalling promoted PDPN expression in cancer cells, thereby enhancing tumour growth and leading to a more invasive phenotype.
Full Text
http://www.sciencedirect.com/science/article/pii/S0003996914000806
DOI
10.1016/j.archoralbio.2014.03.017
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
박광균(Park, Kwang Kyun)
정원윤(Chung, Won Yoon) ORCID logo https://orcid.org/0000-0001-8428-9005
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98649
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