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Stromal transforming growth factor-beta 1 is crucial for reinforcing the invasive potential of low invasive cancer

DC FieldValueLanguage
dc.contributor.author박광균-
dc.contributor.author정원윤-
dc.date.accessioned2015-01-06T16:43:38Z-
dc.date.available2015-01-06T16:43:38Z-
dc.date.issued2014-
dc.identifier.issn0003-9969-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98649-
dc.description.abstractOBJECTIVE: Tumour cells alter the characteristics of the adjacent stroma to create a supportive microenvironment during cancer progression. In vitro and in vivo experiments were carried out to verify the role of stromal TGF-β1 in reinforcing of the invasive potential in low invasive cancer. MATERIALS AND METHODS: Isolated NF or CAF was co-cultured with low invasive HSC-2 cells to evaluate whether stromal TGF-β1 induced PDPN expression by Transwell invasion and influenced tumour growth in orthotopic xenografts. RESULTS: Stimulation by TGF-β1 promoted PDPN expression and Transwell invasion through SMAD signalling as well as activation of Src, P38 mitogen activated protein kinase and extracellular regulated kinase 1/2. PDPN induction was TβRII-dependent. Tumour growth of HSC-2 OSCC in a mouse xenograft was intensified in the tumour CAF microenvironment. CONCLUSIONS: Stromal TGF-β1 signalling promoted PDPN expression in cancer cells, thereby enhancing tumour growth and leading to a more invasive phenotype.-
dc.description.statementOfResponsibilityopen-
dc.format.extent687~694-
dc.relation.isPartOfARCHIVES OF ORAL BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBlotting, Western-
dc.subject.MESHCarcinoma, Squamous Cell/pathology*-
dc.subject.MESHCoculture Techniques-
dc.subject.MESHDisease Progression-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHFibroblasts/metabolism-
dc.subject.MESHHeterografts-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHMembrane Glycoproteins/metabolism-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHMice, Nude-
dc.subject.MESHMouth Neoplasms/pathology*-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHPhenotype-
dc.subject.MESHSignal Transduction-
dc.subject.MESHTransforming Growth Factor beta1/pharmacology*-
dc.subject.MESHTumor Microenvironment-
dc.titleStromal transforming growth factor-beta 1 is crucial for reinforcing the invasive potential of low invasive cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorYoung Sun Hwang-
dc.contributor.googleauthorKwang-Kyun Park-
dc.contributor.googleauthorWon-Yoon Chung-
dc.identifier.doi10.1016/j.archoralbio.2014.03.017-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01429-
dc.contributor.localIdA03676-
dc.relation.journalcodeJ00225-
dc.identifier.eissn1879-1506-
dc.identifier.pmid24769314-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0003996914000806-
dc.subject.keywordFibroblast-
dc.subject.keywordInvasion-
dc.subject.keywordPodoplanin-
dc.subject.keywordStromal-
dc.subject.keywordTransforming growth factor β1-
dc.subject.keywordXenograft-
dc.contributor.alternativeNamePark, Kwang Kyun-
dc.contributor.alternativeNameChung, Won Yoon-
dc.contributor.affiliatedAuthorPark, Kwang Kyun-
dc.contributor.affiliatedAuthorChung, Won Yoon-
dc.rights.accessRightsfree-
dc.citation.volume59-
dc.citation.number7-
dc.citation.startPage687-
dc.citation.endPage694-
dc.identifier.bibliographicCitationARCHIVES OF ORAL BIOLOGY, Vol.59(7) : 687-694, 2014-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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