Cited 13 times in
Stromal transforming growth factor-beta 1 is crucial for reinforcing the invasive potential of low invasive cancer
DC Field | Value | Language |
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dc.contributor.author | 박광균 | - |
dc.contributor.author | 정원윤 | - |
dc.date.accessioned | 2015-01-06T16:43:38Z | - |
dc.date.available | 2015-01-06T16:43:38Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0003-9969 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98649 | - |
dc.description.abstract | OBJECTIVE: Tumour cells alter the characteristics of the adjacent stroma to create a supportive microenvironment during cancer progression. In vitro and in vivo experiments were carried out to verify the role of stromal TGF-β1 in reinforcing of the invasive potential in low invasive cancer. MATERIALS AND METHODS: Isolated NF or CAF was co-cultured with low invasive HSC-2 cells to evaluate whether stromal TGF-β1 induced PDPN expression by Transwell invasion and influenced tumour growth in orthotopic xenografts. RESULTS: Stimulation by TGF-β1 promoted PDPN expression and Transwell invasion through SMAD signalling as well as activation of Src, P38 mitogen activated protein kinase and extracellular regulated kinase 1/2. PDPN induction was TβRII-dependent. Tumour growth of HSC-2 OSCC in a mouse xenograft was intensified in the tumour CAF microenvironment. CONCLUSIONS: Stromal TGF-β1 signalling promoted PDPN expression in cancer cells, thereby enhancing tumour growth and leading to a more invasive phenotype. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 687~694 | - |
dc.relation.isPartOf | ARCHIVES OF ORAL BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Carcinoma, Squamous Cell/pathology* | - |
dc.subject.MESH | Coculture Techniques | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Fibroblasts/metabolism | - |
dc.subject.MESH | Heterografts | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Membrane Glycoproteins/metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Mouth Neoplasms/pathology* | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Transforming Growth Factor beta1/pharmacology* | - |
dc.subject.MESH | Tumor Microenvironment | - |
dc.title | Stromal transforming growth factor-beta 1 is crucial for reinforcing the invasive potential of low invasive cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Young Sun Hwang | - |
dc.contributor.googleauthor | Kwang-Kyun Park | - |
dc.contributor.googleauthor | Won-Yoon Chung | - |
dc.identifier.doi | 10.1016/j.archoralbio.2014.03.017 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01429 | - |
dc.contributor.localId | A03676 | - |
dc.relation.journalcode | J00225 | - |
dc.identifier.eissn | 1879-1506 | - |
dc.identifier.pmid | 24769314 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0003996914000806 | - |
dc.subject.keyword | Fibroblast | - |
dc.subject.keyword | Invasion | - |
dc.subject.keyword | Podoplanin | - |
dc.subject.keyword | Stromal | - |
dc.subject.keyword | Transforming growth factor β1 | - |
dc.subject.keyword | Xenograft | - |
dc.contributor.alternativeName | Park, Kwang Kyun | - |
dc.contributor.alternativeName | Chung, Won Yoon | - |
dc.contributor.affiliatedAuthor | Park, Kwang Kyun | - |
dc.contributor.affiliatedAuthor | Chung, Won Yoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 59 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 687 | - |
dc.citation.endPage | 694 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF ORAL BIOLOGY, Vol.59(7) : 687-694, 2014 | - |
dc.identifier.rimsid | 38173 | - |
dc.type.rims | ART | - |
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