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Reduced Binding Potential of GABA-A/Benzodiazepine Receptors in Individuals at Ultra-high Risk for Psychosis:An [18F]-Fluroflumazenil Positron Emission Tomography Study

 Jee In Kang  ;  Hae-Jeong Park  ;  Se Joo Kim  ;  Kyung Ran Kim  ;  Su Young Lee  ;  Eun Lee  ;  Suk Kyoon An  ;  Jun Soo Kwon  ;  Jong Doo Lee 
 SCHIZOPHRENIA BULLETIN, Vol.40(3) : 548-557, 2014 
Journal Title
Issue Date
Adolescent ; Brain/diagnostic imaging ; Brain/metabolism* ; Case-Control Studies ; Caudate Nucleus/diagnostic imaging ; Caudate Nucleus/metabolism ; Female ; Flumazenil/analogs & derivatives* ; Flumazenil/metabolism ; Hippocampus/diagnostic imaging ; Hippocampus/metabolism ; Humans ; Male ; Nucleus Accumbens/diagnostic imaging ; Nucleus Accumbens/metabolism ; Parahippocampal Gyrus/diagnostic imaging ; Parahippocampal Gyrus/metabolism ; Positron-Emission Tomography ; Prodromal Symptoms* ; Protein Binding ; Putamen/diagnostic imaging ; Putamen/metabolism ; Receptors, GABA-A/metabolism* ; Risk ; Schizophrenia/diagnostic imaging ; Schizophrenia/metabolism* ; Young Adult ; gamma-Aminobutyric Acid/metabolism*
GABA ; PET ; caudate ; fluoroflumazenil ; risk for psychosis ; schizophrenia ; ultra-high
Background: Altered transmission of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter, may contribute to the development of schizophrenia. The purpose of the present study was to investigate the presence of GABA-A/benzodiazepine (BZ) receptor binding abnormalities in individuals at ultra-high risk (UHR) for psychosis in comparison with normal controls using [18F]-fluoroflumazenil (FFMZ) positron emission tomography (PET). In particular, we set regions of interest in the striatum (caudate, putamen, and nucleus accumbens) and medial temporal area (hippocampus and parahippocampal gyrus). Methods: Eleven BZ-naive people at UHR and 15 normal controls underwent PET scanning using [18F]-FFMZ to measure GABA-A/BZ receptor binding potential. The regional group differences between UHR individuals and normal controls were analyzed using Statistical Parametric Mapping 8 software. Participants were evaluated using the structured interview for prodromal syndromes and neurocognitive function tasks. Results: People at UHR demonstrated significantly reduced binding potential of GABA-A/BZ receptors in the right caudate. Conclusions: Altered GABAergic transmission and/or the imbalance of inhibitory and excitatory systems in the striatum may be present at the putative prodromal stage and play a pivotal role in the pathophysiology of psychosis.
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1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jee In(강지인) ORCID logo https://orcid.org/0000-0002-2818-7183
Kim, Kyung Ran(김경란) ORCID logo https://orcid.org/0000-0001-8375-1851
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
An, Suk Kyoon(안석균) ORCID logo https://orcid.org/0000-0003-4576-6184
Lee, Eun(이은) ORCID logo https://orcid.org/0000-0002-7462-0144
Lee, Jong Doo(이종두)
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