Cited 29 times in
Reduced Binding Potential of GABA-A/Benzodiazepine Receptors in Individuals at Ultra-high Risk for Psychosis:An [18F]-Fluroflumazenil Positron Emission Tomography Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강지인 | - |
dc.contributor.author | 김경란 | - |
dc.contributor.author | 김세주 | - |
dc.contributor.author | 박해정 | - |
dc.contributor.author | 안석균 | - |
dc.contributor.author | 이은 | - |
dc.contributor.author | 이종두 | - |
dc.date.accessioned | 2015-01-06T16:41:29Z | - |
dc.date.available | 2015-01-06T16:41:29Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0586-7614 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98579 | - |
dc.description.abstract | Background: Altered transmission of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter, may contribute to the development of schizophrenia. The purpose of the present study was to investigate the presence of GABA-A/benzodiazepine (BZ) receptor binding abnormalities in individuals at ultra-high risk (UHR) for psychosis in comparison with normal controls using [18F]-fluoroflumazenil (FFMZ) positron emission tomography (PET). In particular, we set regions of interest in the striatum (caudate, putamen, and nucleus accumbens) and medial temporal area (hippocampus and parahippocampal gyrus). Methods: Eleven BZ-naive people at UHR and 15 normal controls underwent PET scanning using [18F]-FFMZ to measure GABA-A/BZ receptor binding potential. The regional group differences between UHR individuals and normal controls were analyzed using Statistical Parametric Mapping 8 software. Participants were evaluated using the structured interview for prodromal syndromes and neurocognitive function tasks. Results: People at UHR demonstrated significantly reduced binding potential of GABA-A/BZ receptors in the right caudate. Conclusions: Altered GABAergic transmission and/or the imbalance of inhibitory and excitatory systems in the striatum may be present at the putative prodromal stage and play a pivotal role in the pathophysiology of psychosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | SCHIZOPHRENIA BULLETIN | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Brain/diagnostic imaging | - |
dc.subject.MESH | Brain/metabolism* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Caudate Nucleus/diagnostic imaging | - |
dc.subject.MESH | Caudate Nucleus/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Flumazenil/analogs & derivatives* | - |
dc.subject.MESH | Flumazenil/metabolism | - |
dc.subject.MESH | Hippocampus/diagnostic imaging | - |
dc.subject.MESH | Hippocampus/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Nucleus Accumbens/diagnostic imaging | - |
dc.subject.MESH | Nucleus Accumbens/metabolism | - |
dc.subject.MESH | Parahippocampal Gyrus/diagnostic imaging | - |
dc.subject.MESH | Parahippocampal Gyrus/metabolism | - |
dc.subject.MESH | Positron-Emission Tomography | - |
dc.subject.MESH | Prodromal Symptoms* | - |
dc.subject.MESH | Protein Binding | - |
dc.subject.MESH | Putamen/diagnostic imaging | - |
dc.subject.MESH | Putamen/metabolism | - |
dc.subject.MESH | Receptors, GABA-A/metabolism* | - |
dc.subject.MESH | Risk | - |
dc.subject.MESH | Schizophrenia/diagnostic imaging | - |
dc.subject.MESH | Schizophrenia/metabolism* | - |
dc.subject.MESH | Young Adult | - |
dc.subject.MESH | gamma-Aminobutyric Acid/metabolism* | - |
dc.title | Reduced Binding Potential of GABA-A/Benzodiazepine Receptors in Individuals at Ultra-high Risk for Psychosis:An [18F]-Fluroflumazenil Positron Emission Tomography Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Nuclear Medicine (핵의학) | - |
dc.contributor.googleauthor | Jee In Kang | - |
dc.contributor.googleauthor | Hae-Jeong Park | - |
dc.contributor.googleauthor | Se Joo Kim | - |
dc.contributor.googleauthor | Kyung Ran Kim | - |
dc.contributor.googleauthor | Su Young Lee | - |
dc.contributor.googleauthor | Eun Lee | - |
dc.contributor.googleauthor | Suk Kyoon An | - |
dc.contributor.googleauthor | Jun Soo Kwon | - |
dc.contributor.googleauthor | Jong Doo Lee | - |
dc.identifier.doi | 10.1093/schbul/sbt052 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02227 | - |
dc.contributor.localId | A03032 | - |
dc.contributor.localId | A03138 | - |
dc.contributor.localId | A00084 | - |
dc.contributor.localId | A00293 | - |
dc.contributor.localId | A00604 | - |
dc.contributor.localId | A01730 | - |
dc.relation.journalcode | J02639 | - |
dc.identifier.eissn | 1745-1701 | - |
dc.identifier.pmid | 23588475 | - |
dc.identifier.url | http://schizophreniabulletin.oxfordjournals.org/content/40/3/548.long | - |
dc.subject.keyword | GABA | - |
dc.subject.keyword | PET | - |
dc.subject.keyword | caudate | - |
dc.subject.keyword | fluoroflumazenil | - |
dc.subject.keyword | risk for psychosis | - |
dc.subject.keyword | schizophrenia | - |
dc.subject.keyword | ultra-high | - |
dc.contributor.alternativeName | Kang, Jee In | - |
dc.contributor.alternativeName | Kim, Kyung Ran | - |
dc.contributor.alternativeName | Kim, Se Joo | - |
dc.contributor.alternativeName | Park, Hae Jeong | - |
dc.contributor.alternativeName | An, Suk Kyoon | - |
dc.contributor.alternativeName | Lee, Eun | - |
dc.contributor.alternativeName | Lee, Jong Doo | - |
dc.contributor.affiliatedAuthor | An, Suk Kyoon | - |
dc.contributor.affiliatedAuthor | Lee, Eun | - |
dc.contributor.affiliatedAuthor | Lee, Jong Doo | - |
dc.contributor.affiliatedAuthor | Kang, Jee In | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Ran | - |
dc.contributor.affiliatedAuthor | Kim, Se Joo | - |
dc.contributor.affiliatedAuthor | Park, Hae Jeong | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 40 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 548 | - |
dc.citation.endPage | 557 | - |
dc.identifier.bibliographicCitation | SCHIZOPHRENIA BULLETIN, Vol.40(3) : 548-557, 2014 | - |
dc.identifier.rimsid | 38126 | - |
dc.type.rims | ART | - |
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