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Reduced Binding Potential of GABA-A/Benzodiazepine Receptors in Individuals at Ultra-high Risk for Psychosis:An [18F]-Fluroflumazenil Positron Emission Tomography Study

DC FieldValueLanguage
dc.contributor.author강지인-
dc.contributor.author김경란-
dc.contributor.author김세주-
dc.contributor.author박해정-
dc.contributor.author안석균-
dc.contributor.author이은-
dc.contributor.author이종두-
dc.date.accessioned2015-01-06T16:41:29Z-
dc.date.available2015-01-06T16:41:29Z-
dc.date.issued2014-
dc.identifier.issn0586-7614-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98579-
dc.description.abstractBackground: Altered transmission of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter, may contribute to the development of schizophrenia. The purpose of the present study was to investigate the presence of GABA-A/benzodiazepine (BZ) receptor binding abnormalities in individuals at ultra-high risk (UHR) for psychosis in comparison with normal controls using [18F]-fluoroflumazenil (FFMZ) positron emission tomography (PET). In particular, we set regions of interest in the striatum (caudate, putamen, and nucleus accumbens) and medial temporal area (hippocampus and parahippocampal gyrus). Methods: Eleven BZ-naive people at UHR and 15 normal controls underwent PET scanning using [18F]-FFMZ to measure GABA-A/BZ receptor binding potential. The regional group differences between UHR individuals and normal controls were analyzed using Statistical Parametric Mapping 8 software. Participants were evaluated using the structured interview for prodromal syndromes and neurocognitive function tasks. Results: People at UHR demonstrated significantly reduced binding potential of GABA-A/BZ receptors in the right caudate. Conclusions: Altered GABAergic transmission and/or the imbalance of inhibitory and excitatory systems in the striatum may be present at the putative prodromal stage and play a pivotal role in the pathophysiology of psychosis.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfSchizophrenia Bulletin-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleReduced Binding Potential of GABA-A/Benzodiazepine Receptors in Individuals at Ultra-high Risk for Psychosis:An [18F]-Fluroflumazenil Positron Emission Tomography Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Nuclear Medicine (핵의학)-
dc.contributor.googleauthorJee In Kang-
dc.contributor.googleauthorHae-Jeong Park-
dc.contributor.googleauthorSe Joo Kim-
dc.contributor.googleauthorKyung Ran Kim-
dc.contributor.googleauthorSu Young Lee-
dc.contributor.googleauthorEun Lee-
dc.contributor.googleauthorSuk Kyoon An-
dc.contributor.googleauthorJun Soo Kwon-
dc.contributor.googleauthorJong Doo Lee-
dc.identifier.doi10.1093/schbul/sbt052-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02227-
dc.contributor.localIdA03032-
dc.contributor.localIdA03138-
dc.contributor.localIdA00084-
dc.contributor.localIdA00293-
dc.contributor.localIdA00604-
dc.contributor.localIdA01730-
dc.relation.journalcodeJ02639-
dc.identifier.urlhttp://schizophreniabulletin.oxfordjournals.org/content/40/3/548.long-
dc.contributor.alternativeNameKang, Jee In-
dc.contributor.alternativeNameKim, Kyung Ran-
dc.contributor.alternativeNameKim, Se Joo-
dc.contributor.alternativeNamePark, Hae Jeong-
dc.contributor.alternativeNameAn, Suk Kyoon-
dc.contributor.alternativeNameLee, Eun-
dc.contributor.alternativeNameLee, Jong Doo-
dc.contributor.affiliatedAuthorAn, Suk Kyoon-
dc.contributor.affiliatedAuthorLee, Eun-
dc.contributor.affiliatedAuthorLee, Jong Doo-
dc.contributor.affiliatedAuthorKang, Jee In-
dc.contributor.affiliatedAuthorKim, Kyung Ran-
dc.contributor.affiliatedAuthorKim, Se Joo-
dc.contributor.affiliatedAuthorPark, Hae Jeong-
dc.rights.accessRightsfree-
dc.citation.volume40-
dc.citation.number3-
dc.citation.startPage548-
dc.citation.endPage557-
dc.identifier.bibliographicCitationSchizophrenia Bulletin, Vol.40(3) : 548-557, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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