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Synchrony of anterior cingulate cortex and insular-striatal activation predicts ambiguity aversion in individuals with low impulsivity.

Authors
 Young-Chul Jung  ;  Tilman Schulte  ;  Eva M. Müller-Oehring  ;  William Hawkes  ;  Kee Namkoong  ;  Adolf Pfefferbaum  ;  Edith V. Sullivan 
Citation
 CEREBRAL CORTEX, Vol.24(5) : 1397-1408, 2014 
Journal Title
 CEREBRAL CORTEX 
ISSN
 1047-3211 
Issue Date
2014
MeSH
Adult ; Brain Mapping ; Chi-Square Distribution ; Corpus Striatum/blood supply ; Corpus Striatum/physiopathology* ; Decision Making* ; Disruptive, Impulse Control, and Conduct Disorders/diagnosis* ; Female ; Gyrus Cinguli/blood supply ; Gyrus Cinguli/physiopathology* ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neural Pathways/blood supply ; Oxygen/blood ; Pattern Recognition, Visual ; Photic Stimulation ; Predictive Value of Tests ; Reaction Time ; Uncertainty*
Keywords
ambiguity ; anterior cingulate cortex ; functional connectivity ; impulsivity ; uncertainty
Abstract
Personal attitude toward ambiguity contributes to individual differences in decision making in uncertain situations. Operationally, these attitudes reflect the various coping strategies elected to overcome the limited information. A key brain region involved in cognitive control for performance adjustments is the dorsal anterior cingulate cortex (dACC). To test how dACC functional network connectivity would be modulated by uncertainty and differ between individuals, 24 healthy participants underwent functional MRI in 3 sequential runs: 1 resting-state and 2 decision-making task runs. Individuals with lower nonplanning impulsiveness made greater use of a Pass option and avoided uncertain ambiguous situations. Seed-based functional connectivity analysis during the task runs revealed that stronger activation synchrony between the left dACC and the right anterior insula correlated with greater use of a Pass response option. During the resting-state, stronger resting-state functional connectivity between the left dACC and the ventral striatum predicted the adoption of Pass as a behavioral strategy and correlated with stronger task-activated synchrony between the dACC and the right anterior insula. Our findings indicate that that the synchrony between the dACC and insula-striatal circuitry was greater in individuals with low compared with high nonplanning impulsiveness and contributed to adopting Pass as a useful behavioral strategy.
Full Text
http://cercor.oxfordjournals.org/content/24/5/1397.long
DOI
10.1093/cercor/bht008
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
Jung, Young Chul(정영철) ORCID logo https://orcid.org/0000-0002-0578-2510
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98538
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