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Molecular and engineering approaches to regenerate and repair teeth in mammals

Authors
 Wing-Fu Lai  ;  Jong-Min Lee  ;  Han-Sung Jung 
Citation
 CELLULAR AND MOLECULAR LIFE SCIENCES, Vol.71(9) : 1691-1701, 2014 
Journal Title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN
 1420-682X 
Issue Date
2014
MeSH
Animals ; Bone Morphogenetic Proteins/metabolism ; Humans ; Mammals ; Regeneration ; Tissue Engineering* ; Tissue Scaffolds ; Tooth/growth & development ; Tooth/physiology*
Keywords
Tooth repair ; Tooth regeneration ; Tooth replacement ; Development ; Morphogenesis ; Bioengineering ; Polymeric scaffolds
Abstract
Continuous replacement of teeth throughout the lifespan of an individual is possibly basal for most of the vertebrates including fish and reptiles; however, mammals generally have a limited capacity of tooth renewal. The ability to induce cellular differentiation in adults to replace lost or damaged cells in mammals, or to tissue-engineer organs in vitro, has hence become one of the major goals of regenerative medicine. In this article, we will revisit some of the important signals and tissue interactions that regulate mammalian tooth development, and will offer a synopsis of the latest progress in tooth regeneration and repair via molecular and engineering approaches. It is hoped that this article will not only offer an overview of recent technologies in tooth regeneration and repair but will also stimulate more interdisciplinary research in this field to turn the pursuit of tooth regeneration and repair into practical reality.
Full Text
http://link.springer.com/article/10.1007%2Fs00018-013-1518-7
DOI
10.1007/s00018-013-1518-7
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Lai, Wing Fu(여영부)
Lee, Jong Min(이종민) ORCID logo https://orcid.org/0000-0002-9466-7644
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98520
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