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Epithelial Wound Healing after Cataract Surgery Comparing Two Different Topical Fluoroquinolones

 Kyung Eun Han  ;  Woo Suk Chung  ;  Tae-im Kim  ;  Sekyung Kim  ;  Terry Kim  ;  Eung Kweon Kim 
 YONSEI MEDICAL JOURNAL, Vol.55(1) : 197-202, 2014 
Journal Title
Issue Date
Aged ; Aza Compounds/therapeutic use ; Cataract Extraction ; Cornea/drug effects ; Cornea/surgery* ; Female ; Fluoroquinolones/therapeutic use* ; Humans ; Levofloxacin/therapeutic use ; Male ; Middle Aged ; Quinolines/therapeutic use ; Tomography, Optical Coherence ; Wound Healing/drug effects*
Levofloxacin ; cataract surgery ; epithelial wound healing ; moxifloxacin
PURPOSE: To compare the epithelial wound healing response of two preservative-free fluoroquinolones, moxifloxacin and levofloxacin, in patients who underwent cataract surgery. MATERIALS AND METHODS: In this prospective, evaluator-masked, randomized clinical trial, 59 eyes of 50 patients who underwent cataract surgery were enrolled. Patients were randomized to receive moxifloxacin 0.5% (n=32 eyes) or levofloxacin 0.5% (n=27 eyes). All patients instilled moxifloxacin or levofloxain four times daily for 1 week prior to surgery and 2 weeks after surgery. The epithelial wound healing status in the corneal incision site was scanned with a raster scan mode of fourier-domain optical coherence tomography (FD-OCT). The number of eyes showing epithelial defect images and average number of corneal epithelial defect cuts per eye were compared between groups. All patients were evaluated on postoperative days 1, 2, 3, and 10. RESULTS: On postoperative days 1, 2, and 3, the number of eyes showing epithelial defects in FD-OCT was not statistically different (all p>0.05). The average number of corneal epithelial defect cuts was also not statistically different between the two groups (all p>0.05). No eyes showed epithelial defects on postoperative day 10 in either group. CONCLUSION: There were no differences on epithelial wound healing comparing these two different fluoroquinolones at the incision site of cataract surgery.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Kyung(김세경)
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
Kim, Tae Im(김태임) ORCID logo https://orcid.org/0000-0001-6414-3842
Chung, Woo Suk(정우석)
Han, Kyung Eun(한경은)
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