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Resting-state synchrony between anterior cingulate cortex and precuneus relates to body shape concern in anorexia nervosa and bulimia nervosa

Authors
 Seojung Lee  ;  Kyung Ran Kim  ;  Jeonghun Ku  ;  Jung-Hyun Lee  ;  Kee Namkoong  ;  Young-Chul Jung 
Citation
 PSYCHIATRY RESEARCH, Vol.221(1) : 43-48, 2014 
Journal Title
 PSYCHIATRY RESEARCH 
ISSN
 0165-1781 
Issue Date
2014
MeSH
Adult ; Anorexia Nervosa/physiopathology* ; Anorexia Nervosa/psychology ; Body Image* ; Brain Mapping ; Bulimia Nervosa/physiopathology* ; Bulimia Nervosa/psychology ; Case-Control Studies ; Cerebral Cortex/physiopathology* ; Electroencephalography Phase Synchronization ; Female ; Food* ; Functional Neuroimaging ; Gyrus Cinguli/physiopathology* ; Humans ; Magnetic Resonance Imaging ; Neural Pathways/physiopathology ; Socioeconomic Factors
Keywords
Anorexia nervosa ; Body shape ; Bulimia nervosa ; Precuneus ; Resting state functional connectivity
Abstract
Cortical areas supporting cognitive control and salience demonstrate different neural responses to visual food cues in patients with eating disorders. This top-down cognitive control, which interacts with bottom-up appetitive responses, is tightly integrated not only in task conditions but also in the resting-state. The dorsal anterior cingulate cortex (dACC) is a key node of a large-scale network that is involved in self-referential processing and cognitive control. We investigated resting-state functional connectivity of the dACC and hypothesized that altered connectivity would be demonstrated in cortical midline structures involved in self-referential processing and cognitive control. Seed-based resting-state functional connectivity was analyzed in women with anorexia nervosa (N=18), women with bulimia nervosa (N=20) and age matched healthy controls (N=20). Between group comparisons revealed that the anorexia nervosa group exhibited stronger synchronous activity between the dACC and retrosplenial cortex, whereas the bulimia nervosa group showed stronger synchronous activity between the dACC and medial orbitofrontal cortex. Both groups demonstrated stronger synchronous activity between the dACC and precuneus, which correlated with higher scores of the Body Shape Questionnaire. The dACC-precuneus resting-state synchrony might be associated with the disorder-specific rumination on eating, weight and body shape in patients with eating disorders.
Full Text
http://www.sciencedirect.com/science/article/pii/S0925492713003120
DOI
10.1016/j.pscychresns.2013.11.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Ran(김경란) ORCID logo https://orcid.org/0000-0001-8375-1851
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
Lee, Seo Jung(이서정)
Jung, Young Chul(정영철) ORCID logo https://orcid.org/0000-0002-0578-2510
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98462
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