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Glutathione rescues brain endothelial cells from hydrogen peroxide-induced oxidative stress by activating Nrf2 expression.

Authors
 Juhyun Song  ;  So Mang Kang  ;  Won Taek Lee  ;  Kyung Ah Park  ;  Kyoung Min Lee  ;  Jong Eun Lee 
Citation
 EXPERIMENTAL NEUROBIOLOGY, Vol.23(1) : 93-103, 2014 
Journal Title
 EXPERIMENTAL NEUROBIOLOGY 
ISSN
 1226-2560 
Issue Date
2014
Keywords
Reactive oxygen species (ROS) ; apoptosis ; glutathione (GSH) ; hydrogen peroxide (H2O2) ; murine brain endothelial cells (bEnd.3 cells) ; nuclear factor erythroid 2-related factor 2 (Nrf2)
Abstract
Glutathione (GSH) protects cells against oxidative stress by playing an antioxidant role. Protecting brain endothelial cells under oxidative stress is key to treating cerebrovascular diseases and neurodegenerative diseases including Alzheimer's disease and Huntington's disease. In present study, we investigated the protective effect of GSH on brain endothelial cells against hydrogen peroxide (H2O2). We showed that GSH attenuates H2O2-induced production of nitric oxide (NO), reactive oxygen species (ROS), and 8-Oxo-2'-deoxyguanosine (8-OHdG), an oxidized form of deoxiguanosine. GSH also prevents H2O2-induced reduction of tight junction proteins. Finally, GSH increases the level of nuclear factor erythroid 2-related factor 2 (Nrf2) and activates Nrf2-mediated signaling pathways. Thus, GSH is a promising target to protect brain endothelial cells in conditions of brain injury and disease.
Files in This Item:
T201400841.pdf Download
DOI
10.5607/en.2014.23.1.93
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Park, Kyung Ah(박경아)
Song, Ju Hyun(송주현)
Lee, Won Taek(이원택) ORCID logo https://orcid.org/0000-0001-7348-9562
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98407
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