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Abnormal Neural Processing during Emotional Salience atrtibution of affective asymmetry in patients with schizophrenia

Authors
 Seon-Koo Lee  ;  Ji Won Chun  ;  Jung Suk Lee  ;  Hae-Jeong Park  ;  Young-Chul Jung  ;  Jeong-Ho Seok  ;  Jae-Jin Kim 
Citation
 PLOS ONE, Vol.9(3) : e90792, 2014 
Journal Title
 PLOS ONE 
Issue Date
2014
MeSH
Adult ; Affect* ; Brain/pathology ; Brain Mapping ; Case-Control Studies ; Emotions* ; Female ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Risk Factors ; Schizophrenia/diagnosis ; Schizophrenia/physiopathology*
Abstract
Aberrant emotional salience attribution has been reported to be an important clinical feature in patients with schizophrenia. Real life stimuli that incorporate both positive and negative emotional traits lead to affective asymmetry such as negativity bias and positivity offset. In this study, we investigated the neural correlates of emotional salience attribution in patients with schizophrenia when affective asymmetry was processed. Fifteen patients with schizophrenia and 14 healthy controls were scanned using functional magnetic resonance imaging (fMRI) while performing an emotion judgment task in which two pictures were juxtaposed. The task consisted of responding to affective asymmetry condition (ambivalent and neutral) and affective symmetry conditions (positive and negative), and group comparisons were performed for each condition. Significantly higher activity in the medial prefrontal cortex and inferior frontal gyrus was observed for the ambivalent condition than for the other conditions in controls, but not in patients. Compared with controls, patients showed decreased activities in the dorsolateral prefrontal cortex, dorsal anterior cingulate cortex, insula, and putamen for the ambivalent condition, but no changes were observed for the neutral condition. Multiple prefrontal hypoactivities during salience attribution of negativity bias in schizophrenia may underlie deficits in the integrative processing of emotional information. Regional abnormalities in the salience network may be the basis of defective emotional salience attribution in schizophrenia, which is likely involved in symptom formation and social dysfunction.
Files in This Item:
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DOI
10.1371/journal.pone.0090792
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
Seok, Jeong Ho(석정호) ORCID logo https://orcid.org/0000-0002-9402-7591
Jung, Young Chul(정영철) ORCID logo https://orcid.org/0000-0002-0578-2510
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98275
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