Cited 22 times in
Abnormal Neural Processing during Emotional Salience atrtibution of affective asymmetry in patients with schizophrenia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박해정 | - |
dc.contributor.author | 석정호 | - |
dc.contributor.author | 정영철 | - |
dc.contributor.author | 김재진 | - |
dc.date.accessioned | 2015-01-06T16:31:42Z | - |
dc.date.available | 2015-01-06T16:31:42Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98275 | - |
dc.description.abstract | Aberrant emotional salience attribution has been reported to be an important clinical feature in patients with schizophrenia. Real life stimuli that incorporate both positive and negative emotional traits lead to affective asymmetry such as negativity bias and positivity offset. In this study, we investigated the neural correlates of emotional salience attribution in patients with schizophrenia when affective asymmetry was processed. Fifteen patients with schizophrenia and 14 healthy controls were scanned using functional magnetic resonance imaging (fMRI) while performing an emotion judgment task in which two pictures were juxtaposed. The task consisted of responding to affective asymmetry condition (ambivalent and neutral) and affective symmetry conditions (positive and negative), and group comparisons were performed for each condition. Significantly higher activity in the medial prefrontal cortex and inferior frontal gyrus was observed for the ambivalent condition than for the other conditions in controls, but not in patients. Compared with controls, patients showed decreased activities in the dorsolateral prefrontal cortex, dorsal anterior cingulate cortex, insula, and putamen for the ambivalent condition, but no changes were observed for the neutral condition. Multiple prefrontal hypoactivities during salience attribution of negativity bias in schizophrenia may underlie deficits in the integrative processing of emotional information. Regional abnormalities in the salience network may be the basis of defective emotional salience attribution in schizophrenia, which is likely involved in symptom formation and social dysfunction. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e90792 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Affect* | - |
dc.subject.MESH | Brain/pathology | - |
dc.subject.MESH | Brain Mapping | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Emotions* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Image Processing, Computer-Assisted | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Schizophrenia/diagnosis | - |
dc.subject.MESH | Schizophrenia/physiopathology* | - |
dc.title | Abnormal Neural Processing during Emotional Salience atrtibution of affective asymmetry in patients with schizophrenia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | Seon-Koo Lee | - |
dc.contributor.googleauthor | Ji Won Chun | - |
dc.contributor.googleauthor | Jung Suk Lee | - |
dc.contributor.googleauthor | Hae-Jeong Park | - |
dc.contributor.googleauthor | Young-Chul Jung | - |
dc.contributor.googleauthor | Jeong-Ho Seok | - |
dc.contributor.googleauthor | Jae-Jin Kim | - |
dc.identifier.doi | 10.1371/journal.pone.0090792 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03656 | - |
dc.contributor.localId | A01730 | - |
dc.contributor.localId | A01929 | - |
dc.contributor.localId | A00870 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 24619004 | - |
dc.contributor.alternativeName | Park, Hae Jeong | - |
dc.contributor.alternativeName | Seok, Jeong Ho | - |
dc.contributor.alternativeName | Jung, Young Chul | - |
dc.contributor.alternativeName | Kim, Jae Jin | - |
dc.contributor.affiliatedAuthor | Jung, Young Chul | - |
dc.contributor.affiliatedAuthor | Park, Hae Jeong | - |
dc.contributor.affiliatedAuthor | Seok, Jeong Ho | - |
dc.contributor.affiliatedAuthor | Kim, Jae Jin | - |
dc.citation.volume | 9 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | e90792 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.9(3) : e90792, 2014 | - |
dc.identifier.rimsid | 51808 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.