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Is vitamin D status associated with open-angle glaucoma? A cross-sectional study from South Korea

 Tae Keun Yoo  ;  Ein Oh  ;  Samin Hong 
 PUBLIC HEALTH NUTRITION, Vol.17(4) : 833-843, 2014 
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Aged ; Asian Continental Ancestry Group ; Cross-Sectional Studies ; Female ; Glaucoma, Open-Angle/epidemiology* ; Humans ; Intraocular Pressure ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Nutrition Surveys ; Nutritional Status* ; Odds Ratio ; Prevalence ; Republic of Korea ; Risk Factors ; Vitamin D/administration & dosage ; Vitamin D/blood* ; Vitamin D Deficiency/epidemiology*
OBJECTIVE: Open-angle glaucoma (OAG) is one of the major chronic diseases involving the optic nerve. However, little is known about the association between vitamin D and OAG. The present study was conducted to test the hypothesis that lower vitamin D status is associated with greater prevalence of OAG. DESIGN: Cross-sectional study. Multivariable logistic regression was performed to examine the relationship between serum 25-hydroxyvitamin D (25(OH)D) and OAG after adjusting for traditional potential confounders. OAG was defined by the criteria of the International Society for Geographical and Epidemiological Ophthalmology. SETTING: The Fifth Korean National Health and Nutrition Examination Survey conducted in 2010-2011. SUBJECTS: Six thousand and ninety-four adult participants randomly selected from 192 surveys in 131 locations in South Korea. RESULTS: Multivariable-adjusted odds ratios of OAG across quintiles of decreasing 25(OH)D were 1.26, 1.00 (reference), 1.31, 1.36 and 1.69 (P for quadratic trend <0.01). The odds ratio for the lowest 25(OH)D quintile was significantly higher than that for the second quintile (P < 0.01). In addition, we discovered that the predictors for worsening of OAG, such as intraocular pressure or vertical and horizontal cup-to-disc ratios, had a significant relationship with 25(OH)D level. CONCLUSIONS: There was a reverse J-shaped association between 25(OH)D levels and the risk of OAG, with significantly elevated risk at lower 25(OH)D. The findings of this research suggest that vitamin D deficiency should be considered as a potential risk factor for the development of OAG. To our knowledge, the present study is the first one that shows an association between vitamin D status and OAG.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Hong, Sa Min(홍사민)
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