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Molecular Classification of Metaplastic Carcinoma Using Surrogate Immunohistochemical Staining

 Kim H.M.  ;  Kim D.H.  ;  Jung W.H.  ;  Koo J.S. 
 PATHOBIOLOGY, Vol.81(2) : 69-77, 2014 
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Biomarkers, Tumor/analysis* ; Breast Neoplasms/classification* ; Breast Neoplasms/metabolism* ; Breast Neoplasms/pathology ; Carcinoma/classification* ; Carcinoma/metabolism* ; Carcinoma/pathology ; Female ; Humans ; Immunohistochemistry ; Middle Aged ; Tissue Array Analysis
Objective: The purpose of this study is to investigate molecular subtyping and its implications on metaplastic carcinoma according to surrogate immunohistochemical (IHC) staining. Methods: Following tissue microarray analysis of 34 cases of metaplastic carcinoma, IHC staining for cytokeratin (CK) 5/6, epidermal growth factor receptor (EGFR), claudin-3, claudin-4, claudin-7, E-cadherin, STAT-1, androgen receptor and GGT was performed and classified into basal-like, molecular apocrine, claudin-low, immune-related, mixed and null types. Results: Among the 34 cases of metaplastic carcinoma, 13 were of the basal-like type (35.2%), 9 of the mixed type (26.5%), 8 of the null type (23.5%), 3 of the claudin-low type (8.8%), and 1 was of the molecular apocrine type (2.9%). Depending on the cell type, there were differences between molecular subtypes, with the matrix-producing type occupying the largest proportion in the basal-like, null and mixed types. The spindle cell type represented the largest proportion in the claudin-low and molecular apocrine types, and the squamous cell type characterized the largest proportion in the basal-like type. Conclusion: Following molecular subtyping of metaplastic carcinomas using surrogate IHC markers, the largest number of cases was of the basal-like type, followed by the mixed, null, claudin-low and molecular apocrine types. There were differences between molecular subtypes according to the cell type.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Kim, Do Hee(김도희)
Kim, Hye Min(김혜민) ORCID logo https://orcid.org/0000-0002-2899-9480
Jung, Woo Hee(정우희)
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