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Molecular Classification of Metaplastic Carcinoma Using Surrogate Immunohistochemical Staining

DC FieldValueLanguage
dc.contributor.author구자승-
dc.contributor.author김도희-
dc.contributor.author정우희-
dc.contributor.author김혜민-
dc.date.accessioned2015-01-06T16:28:15Z-
dc.date.available2015-01-06T16:28:15Z-
dc.date.issued2014-
dc.identifier.issn1015-2008-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98165-
dc.description.abstractObjective: The purpose of this study is to investigate molecular subtyping and its implications on metaplastic carcinoma according to surrogate immunohistochemical (IHC) staining. Methods: Following tissue microarray analysis of 34 cases of metaplastic carcinoma, IHC staining for cytokeratin (CK) 5/6, epidermal growth factor receptor (EGFR), claudin-3, claudin-4, claudin-7, E-cadherin, STAT-1, androgen receptor and GGT was performed and classified into basal-like, molecular apocrine, claudin-low, immune-related, mixed and null types. Results: Among the 34 cases of metaplastic carcinoma, 13 were of the basal-like type (35.2%), 9 of the mixed type (26.5%), 8 of the null type (23.5%), 3 of the claudin-low type (8.8%), and 1 was of the molecular apocrine type (2.9%). Depending on the cell type, there were differences between molecular subtypes, with the matrix-producing type occupying the largest proportion in the basal-like, null and mixed types. The spindle cell type represented the largest proportion in the claudin-low and molecular apocrine types, and the squamous cell type characterized the largest proportion in the basal-like type. Conclusion: Following molecular subtyping of metaplastic carcinomas using surrogate IHC markers, the largest number of cases was of the basal-like type, followed by the mixed, null, claudin-low and molecular apocrine types. There were differences between molecular subtypes according to the cell type.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfPATHOBIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBiomarkers, Tumor/analysis*-
dc.subject.MESHBreast Neoplasms/classification*-
dc.subject.MESHBreast Neoplasms/metabolism*-
dc.subject.MESHBreast Neoplasms/pathology-
dc.subject.MESHCarcinoma/classification*-
dc.subject.MESHCarcinoma/metabolism*-
dc.subject.MESHCarcinoma/pathology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMiddle Aged-
dc.subject.MESHTissue Array Analysis-
dc.titleMolecular Classification of Metaplastic Carcinoma Using Surrogate Immunohistochemical Staining-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorKim H.M.-
dc.contributor.googleauthorKim D.H.-
dc.contributor.googleauthorJung W.H.-
dc.contributor.googleauthorKoo J.S.-
dc.identifier.doi10.1159/000354270-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00198-
dc.contributor.localIdA03671-
dc.contributor.localIdA00395-
dc.relation.journalcodeJ02470-
dc.identifier.eissn1423-0291-
dc.identifier.pmid24356094-
dc.identifier.urlhttp://www.karger.com/Article/FullText/354270-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNameKim, Do Hee-
dc.contributor.alternativeNameJung, Woo Hee-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthorJung, Woo Hee-
dc.contributor.affiliatedAuthorKim, Do Hee-
dc.contributor.affiliatedAuthor구자승-
dc.rights.accessRightsfree-
dc.citation.volume81-
dc.citation.number2-
dc.citation.startPage69-
dc.citation.endPage77-
dc.identifier.bibliographicCitationPATHOBIOLOGY, Vol.81(2) : 69-77, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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