Cited 5 times in
Molecular Classification of Metaplastic Carcinoma Using Surrogate Immunohistochemical Staining
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 김도희 | - |
dc.contributor.author | 정우희 | - |
dc.contributor.author | 김혜민 | - |
dc.date.accessioned | 2015-01-06T16:28:15Z | - |
dc.date.available | 2015-01-06T16:28:15Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1015-2008 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98165 | - |
dc.description.abstract | Objective: The purpose of this study is to investigate molecular subtyping and its implications on metaplastic carcinoma according to surrogate immunohistochemical (IHC) staining. Methods: Following tissue microarray analysis of 34 cases of metaplastic carcinoma, IHC staining for cytokeratin (CK) 5/6, epidermal growth factor receptor (EGFR), claudin-3, claudin-4, claudin-7, E-cadherin, STAT-1, androgen receptor and GGT was performed and classified into basal-like, molecular apocrine, claudin-low, immune-related, mixed and null types. Results: Among the 34 cases of metaplastic carcinoma, 13 were of the basal-like type (35.2%), 9 of the mixed type (26.5%), 8 of the null type (23.5%), 3 of the claudin-low type (8.8%), and 1 was of the molecular apocrine type (2.9%). Depending on the cell type, there were differences between molecular subtypes, with the matrix-producing type occupying the largest proportion in the basal-like, null and mixed types. The spindle cell type represented the largest proportion in the claudin-low and molecular apocrine types, and the squamous cell type characterized the largest proportion in the basal-like type. Conclusion: Following molecular subtyping of metaplastic carcinomas using surrogate IHC markers, the largest number of cases was of the basal-like type, followed by the mixed, null, claudin-low and molecular apocrine types. There were differences between molecular subtypes according to the cell type. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | PATHOBIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Biomarkers, Tumor/analysis* | - |
dc.subject.MESH | Breast Neoplasms/classification* | - |
dc.subject.MESH | Breast Neoplasms/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Carcinoma/classification* | - |
dc.subject.MESH | Carcinoma/metabolism* | - |
dc.subject.MESH | Carcinoma/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Tissue Array Analysis | - |
dc.title | Molecular Classification of Metaplastic Carcinoma Using Surrogate Immunohistochemical Staining | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Kim H.M. | - |
dc.contributor.googleauthor | Kim D.H. | - |
dc.contributor.googleauthor | Jung W.H. | - |
dc.contributor.googleauthor | Koo J.S. | - |
dc.identifier.doi | 10.1159/000354270 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A03671 | - |
dc.contributor.localId | A00395 | - |
dc.relation.journalcode | J02470 | - |
dc.identifier.eissn | 1423-0291 | - |
dc.identifier.pmid | 24356094 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/354270 | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Kim, Do Hee | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Kim, Do Hee | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 81 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 69 | - |
dc.citation.endPage | 77 | - |
dc.identifier.bibliographicCitation | PATHOBIOLOGY, Vol.81(2) : 69-77, 2014 | - |
dc.identifier.rimsid | 50691 | - |
dc.type.rims | ART | - |
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