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HMG CoA Reductase Inhibitor Treatment Induces Dysglycemia in Renal Allograft Recipients

 Eun Yeong Choe  ;  Hye Jin Wang  ;  Obin Kwon  ;  Yongin Cho  ;  Kyu Ha Huh  ;  Myoung Soo Kim  ;  Yu Seun Kim  ;  Chul Woo Ahn  ;  Bong Soo Cha  ;  Hyun Chul Lee  ;  Eun Seok Kang 
 Transplantation, Vol.97(4) : 419-425, 2014 
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BACKGROUND: Dysglycemia and dyslipidemia are important metabolic complications of organ transplantation. Statins are widely used to control dyslipidemia; however, long-term use of statins is related to diabetes mellitus (DM) and impaired fasting glucose (IFG). The aim of this study was to evaluate the influence of statins on the development of dysglycemia (IFG and/or DM) in renal allograft recipients. METHODS: A total of 394 patients without previously known DM or IFG who underwent kidney transplantation were enrolled. Patients were grouped into the two groups according to the use of statin (control, n=149; statin, n=245). The major statins used were fluvastatin (80 mg/d, n=134) and atorvastatin (20 mg/d, n=111). We compared the incidence of IFG or DM during the follow-up period. RESULTS: The incidence of IFG was higher in the statin group than that in the control group (28.6% vs. 8.7%, P<0.001). The incidence of dysglycemia was significantly higher in the statin group (40.0% vs. 15.4%, P=0.001). Time to development of dysglycemia after transplantation was shorter in the statin group than in the control group (38.8±29.7 vs. 47.2±23.3 months, P=0.002). Statin use was associated with an increased risk for dysglycemia after adjustment for age, sex, body mass index, hypertension, cholesterol levels, hepatitis C infection, and type of immunosuppressant (hazard ratio=3.08, 95% confidence interval=1.91-4.98). The dysglycemic effect was more profound in the patients who used atorvastatin than in those who used fluvastatin (hazard ratio=2.21, 95% confidence interval=1.02-4.76). CONCLUSION: Statin treatment is associated with an elevation in fasting plasma glucose and in the development of dysglycemia in renal allograft recipients.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
강은석(Kang, Eun Seok) ORCID logo https://orcid.org/0000-0002-0364-4675
권오빈(Kwon, O Bin)
김명수(Kim, Myoung Soo) ORCID logo https://orcid.org/0000-0002-8975-8381
김유선(Kim, Yu Seun) ORCID logo https://orcid.org/0000-0002-5105-1567
안철우(Ahn, Chul Woo) ORCID logo https://orcid.org/0000-0003-3733-7486
왕혜진(Wang, Hye Jin)
이현철(Lee, Hyun Chul)
조용인(Cho, Yong In) ORCID logo https://orcid.org/0000-0002-4645-816X
차봉수(Cha, Bong Soo) ORCID logo https://orcid.org/0000-0003-0542-2854
최은영(Choe, Eun Yeong)
허규하(Huh, Kyu Ha) ORCID logo https://orcid.org/0000-0003-1364-6989
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