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Association between vitamin D deficiency and tuberculosis in a Korean population.

Authors
 Hong, J. Y.  ;  Kim, S. Y.  ;  Chung, K. S.  ;  Kim, E. Y.  ;  Jung, J. Y.  ;  Park, M. S.  ;  Kim, Y. S.  ;  Kim, S. K.  ;  Chang, J.  ;  Kang, Y. A. 
Citation
 International Journal of Tuberculosis and Lung Disease, Vol.18(1) : 73-78, 2014 
Journal Title
 International Journal of Tuberculosis and Lung Disease 
ISSN
 1027-3719 
Issue Date
2014
MeSH
Adult ; Antitubercular Agents/therapeutic use ; Biomarkers/blood ; Chi-Square Distribution ; Female ; Health Surveys ; Humans ; Logistic Models ; Male ; Multivariate Analysis ; Odds Ratio ; Prevalence ; Republic of Korea/epidemiology ; Risk Factors ; Severity of Illness Index ; Treatment Outcome ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/epidemiology* ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/diagnosis ; Vitamin D Deficiency/epidemiology* ; Young Adult
Keywords
TB ; vitamin D deficiency
Abstract
BACKGROUND: Several in vitro studies have been conducted regarding the immunomodulatory and mycobactericidal roles of vitamin D in tuberculous infection. However, discrepancies exist among epidemiological studies. We compared vitamin D deficiency between patients with tuberculosis (TB) and healthy control subjects and identified risk factors for vitamin D deficiency. METHOD: This was an age- and sex-matched case-control analysis of 94 TB cohort and 282 Korean national survey participants. RESULTS: The median baseline 25-hydroxyvitamin D (25[OH]D) level in the TB group (9.86 ng/ml, IQR 7.19–14.15) was lower than in controls (16.03 ng/ml, IQR 12.38–20.30, P < 0.001). The prevalence of severe vitamin D deficiency was higher in patients with TB (51.1%) than in controls (8.2%, P = 0.001). The median 25(OH)D level increased from 11.40 ng/ml (IQR 7.85–15.73) to 13.18 ng/ml (IQR 10.60–19.71) after treatment completion (P = 0.037). On multivariate analysis, presence of TB and history of TB were independently associated with severe vitamin D deficiency. CONCLUSION: Patients with TB had a higher prevalence of vitamin D deficiency than control subjects in a Korean population. The median 25(OH)D level increased after TB treatment. Further studies are needed to establish a causal relationship.
Full Text
http://www.ingentaconnect.com/content/iuatld/ijtld/2014/00000018/00000001/art00015?token=00571c890c560e088d217b76504c486646704549442f243f252d316a332b25757d5c4f6d4e227a947004613
DOI
10.5588/ijtld.13.0536
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Kim, Se Kyu(김세규)
Kim, Song Yee(김송이) ORCID logo https://orcid.org/0000-0001-8627-486X
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Kim, Eun Young(김은영) ORCID logo https://orcid.org/0000-0002-3281-5744
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
Jung, Kyung Soo(정경수) ORCID logo https://orcid.org/0000-0003-1604-8730
Jung, Ji Ye(정지예) ORCID logo https://orcid.org/0000-0003-1589-4142
Hong , Ji Young(홍지영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98083
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