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Association between vitamin D deficiency and tuberculosis in a Korean population.

 Hong, J. Y.  ;  Kim, S. Y.  ;  Chung, K. S.  ;  Kim, E. Y.  ;  Jung, J. Y.  ;  Park, M. S.  ;  Kim, Y. S.  ;  Kim, S. K.  ;  Chang, J.  ;  Kang, Y. A. 
 International Journal of Tuberculosis and Lung Disease, Vol.18(1) : 73-78, 2014 
Journal Title
 International Journal of Tuberculosis and Lung Disease 
Issue Date
BACKGROUND: Several in vitro studies have been conducted regarding the immunomodulatory and mycobactericidal roles of vitamin D in tuberculous infection. However, discrepancies exist among epidemiological studies. We compared vitamin D deficiency between patients with tuberculosis (TB) and healthy control subjects and identified risk factors for vitamin D deficiency. METHOD: This was an age- and sex-matched case-control analysis of 94 TB cohort and 282 Korean national survey participants. RESULTS: The median baseline 25-hydroxyvitamin D (25[OH]D) level in the TB group (9.86 ng/ml, IQR 7.19–14.15) was lower than in controls (16.03 ng/ml, IQR 12.38–20.30, P < 0.001). The prevalence of severe vitamin D deficiency was higher in patients with TB (51.1%) than in controls (8.2%, P = 0.001). The median 25(OH)D level increased from 11.40 ng/ml (IQR 7.85–15.73) to 13.18 ng/ml (IQR 10.60–19.71) after treatment completion (P = 0.037). On multivariate analysis, presence of TB and history of TB were independently associated with severe vitamin D deficiency. CONCLUSION: Patients with TB had a higher prevalence of vitamin D deficiency than control subjects in a Korean population. The median 25(OH)D level increased after TB treatment. Further studies are needed to establish a causal relationship.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강영애(Kang, Young Ae) ORCID logo https://orcid.org/0000-0002-7783-5271
김세규(Kim, Se Kyu)
김송이(Kim, Song Yee) ORCID logo https://orcid.org/0000-0001-8627-486X
김영삼(Kim, Young Sam) ORCID logo https://orcid.org/0000-0001-9656-8482
김은영(Kim, Eun Young)
박무석(Park, Moo Suk) ORCID logo https://orcid.org/0000-0003-0820-7615
장준(Chang, Joon)
정경수(Jung, Kyung Soo) ORCID logo https://orcid.org/0000-0003-1604-8730
정지예(Jung, Ji Ye) ORCID logo https://orcid.org/0000-0003-1589-4142
홍지영(Hong , Ji Young)
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