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Association between vitamin D deficiency and tuberculosis in a Korean population.

DC Field Value Language
dc.contributor.author강영애-
dc.contributor.author김세규-
dc.contributor.author김송이-
dc.contributor.author김영삼-
dc.contributor.author김은영-
dc.contributor.author박무석-
dc.contributor.author장준-
dc.contributor.author정경수-
dc.contributor.author정지예-
dc.contributor.author홍지영-
dc.date.accessioned2015-01-06T16:25:36Z-
dc.date.available2015-01-06T16:25:36Z-
dc.date.issued2014-
dc.identifier.issn1027-3719-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98083-
dc.description.abstractBACKGROUND: Several in vitro studies have been conducted regarding the immunomodulatory and mycobactericidal roles of vitamin D in tuberculous infection. However, discrepancies exist among epidemiological studies. We compared vitamin D deficiency between patients with tuberculosis (TB) and healthy control subjects and identified risk factors for vitamin D deficiency. METHOD: This was an age- and sex-matched case-control analysis of 94 TB cohort and 282 Korean national survey participants. RESULTS: The median baseline 25-hydroxyvitamin D (25[OH]D) level in the TB group (9.86 ng/ml, IQR 7.19–14.15) was lower than in controls (16.03 ng/ml, IQR 12.38–20.30, P < 0.001). The prevalence of severe vitamin D deficiency was higher in patients with TB (51.1%) than in controls (8.2%, P = 0.001). The median 25(OH)D level increased from 11.40 ng/ml (IQR 7.85–15.73) to 13.18 ng/ml (IQR 10.60–19.71) after treatment completion (P = 0.037). On multivariate analysis, presence of TB and history of TB were independently associated with severe vitamin D deficiency. CONCLUSION: Patients with TB had a higher prevalence of vitamin D deficiency than control subjects in a Korean population. The median 25(OH)D level increased after TB treatment. Further studies are needed to establish a causal relationship.-
dc.description.statementOfResponsibilityopen-
dc.format.extent73~78-
dc.languageEnglish-
dc.publisherThe Union-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAntitubercular Agents/therapeutic use-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHFemale-
dc.subject.MESHHealth Surveys-
dc.subject.MESHHumans-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPrevalence-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRisk Factors-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHTuberculosis/diagnosis-
dc.subject.MESHTuberculosis/drug therapy-
dc.subject.MESHTuberculosis/epidemiology*-
dc.subject.MESHVitamin D/analogs & derivatives-
dc.subject.MESHVitamin D/blood-
dc.subject.MESHVitamin D Deficiency/blood-
dc.subject.MESHVitamin D Deficiency/diagnosis-
dc.subject.MESHVitamin D Deficiency/epidemiology*-
dc.subject.MESHYoung Adult-
dc.titleAssociation between vitamin D deficiency and tuberculosis in a Korean population.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHong, J. Y.-
dc.contributor.googleauthorKim, S. Y.-
dc.contributor.googleauthorChung, K. S.-
dc.contributor.googleauthorKim, E. Y.-
dc.contributor.googleauthorJung, J. Y.-
dc.contributor.googleauthorPark, M. S.-
dc.contributor.googleauthorKim, Y. S.-
dc.contributor.googleauthorKim, S. K.-
dc.contributor.googleauthorChang, J.-
dc.contributor.googleauthorKang, Y. A.-
dc.identifier.doi10.5588/ijtld.13.0536-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00057-
dc.contributor.localIdA00602-
dc.contributor.localIdA00626-
dc.contributor.localIdA00707-
dc.contributor.localIdA01457-
dc.contributor.localIdA03472-
dc.contributor.localIdA03570-
dc.contributor.localIdA03735-
dc.contributor.localIdA04441-
dc.contributor.localIdA00811-
dc.relation.journalcodeJ01167-
dc.identifier.eissn1815-7920-
dc.identifier.pmid24365556-
dc.identifier.urlhttp://www.ingentaconnect.com/content/iuatld/ijtld/2014/00000018/00000001/art00015?token=00571c890c560e088d217b76504c486646704549442f243f252d316a332b25757d5c4f6d4e227a947004613-
dc.subject.keywordTB-
dc.subject.keywordvitamin D deficiency-
dc.contributor.alternativeNameKang, Young Ae-
dc.contributor.alternativeNameKim, Se Kyu-
dc.contributor.alternativeNameKim, Song Yi-
dc.contributor.alternativeNameKim, Young Sam-
dc.contributor.alternativeNameKim, Eun Young-
dc.contributor.alternativeNamePark, Moo Suk-
dc.contributor.alternativeNameChang, Joon-
dc.contributor.alternativeNameJung, Kyung Soo-
dc.contributor.alternativeNameJung, Ji Ye-
dc.contributor.alternativeNameHong, Ji Young-
dc.contributor.affiliatedAuthorKang, Young Ae-
dc.contributor.affiliatedAuthorKim, Se Kyu-
dc.contributor.affiliatedAuthorKim, Song Yi-
dc.contributor.affiliatedAuthorKim, Young Sam-
dc.contributor.affiliatedAuthorPark, Moo Suk-
dc.contributor.affiliatedAuthorChang, Joon-
dc.contributor.affiliatedAuthorJung, Kyung Soo-
dc.contributor.affiliatedAuthorJung, Ji Ye-
dc.contributor.affiliatedAuthorHong , Ji Young-
dc.contributor.affiliatedAuthorKim, Eun Young-
dc.rights.accessRightsfree-
dc.citation.volume18-
dc.citation.number1-
dc.citation.startPage73-
dc.citation.endPage78-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol.18(1) : 73-78, 2014-
dc.identifier.rimsid54876-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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