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Apoptosis signal regulating kinase 1 (ASK1): Potential as a therapeutic target for Alzheimer’s disease.

Authors
 Juhyun Song  ;  Kyung Ah Park  ;  Won Taek Lee  ;  Jong Eun Lee 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.15(2) : 2119-2129, 2014 
Journal Title
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 
Issue Date
2014
MeSH
Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism* ; Amyloid beta-Peptides/metabolism ; Animals ; Endoplasmic Reticulum Stress ; Humans ; Insulin/metabolism ; MAP Kinase Kinase Kinase 5/metabolism* ; Oxidative Stress ; Signal Transduction
Keywords
apoptosis signal regulating kinase 1 (ASK1) ; Alzheimer’s disease (AD) ; oxidative stress ; endoplasmic reticulum (ER) stress ; Aβ neurotoxicity ; tau protein phosphorylation ; insulin signal transduction
Abstract
Alzheimer’s disease (AD) is the most common form of dementia, characterized by a decline in memory and cognitive function. Clinical manifestations of AD are closely associated with the formation of senile plaques and neurofibrillary tangles, neuronal loss and cognitive decline. Apoptosis signal regulating kinase 1 (ASK1) is a mediator of the MAPK pathway, which regulates various cellular responses such as apoptosis, cell survival, and differentiation. Accumulating evidence indicates that ASK1 plays a key role in the pathogenesis of neurodegenerative disorders such as Huntington’s disease and AD. Of particular interest, ASK1 is associated with many signaling pathways, which include endoplasmic reticulum (ER) stress-mediated apoptosis, Aβ-induced neurotoxicity, tau protein phosphorylation, and insulin signal transduction. Here, we review experimental evidence that links ASK1 signaling and AD pathogenesis and propose that ASK1 might be a new point of therapeutic intervention to prevent or treat AD.
Files in This Item:
T201400210.pdf Download
DOI
10.3390/ijms15022119
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Park, Kyung Ah(박경아)
Song, Ju Hyun(송주현)
Lee, Won Taek(이원택) ORCID logo https://orcid.org/0000-0001-7348-9562
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98049
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