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Two-year outcome after combination theraphy for polypoidal choroidal vasculopathy: comparison with photodynamic monotheraphy and anti-vascular endothelial growth factor monotherapy

 Kang H.M.  ;  Koh H.J. 
 OPHTHALMOLOGICA, Vol.231(2) : 86-93, 2014 
Journal Title
Issue Date
Angiogenesis Inhibitors/administration & dosage ; Antibodies, Monoclonal, Humanized/administration & dosage* ; Bevacizumab ; Choroid/blood supply ; Choroid Diseases/diagnosis ; Choroid Diseases/drug therapy* ; Fluorescein Angiography ; Follow-Up Studies ; Fundus Oculi ; Infusions, Intravenous ; Intravitreal Injections ; Photochemotherapy/methods* ; Photosensitizing Agents/administration & dosage ; Porphyrins/administration & dosage* ; Retrospective Studies ; Time Factors ; Tomography, Optical Coherence ; Treatment Outcome ; Vascular Endothelial Growth Factor A/antagonists & inhibitors* ; Visual Acuity
Anti-vascular endothelial growth factor therapy ; Combination therapy ; Photodynamic therapy ; Polypoidal choroidal vasculopathy
Purpose: To compare treatment outcomes of photodynamic therapy (PDT), anti-vascular endothelial growth factor (VEGF) therapy and PDT combined with anti-VEGF therapy for polypoidal choroidal vasculopathy (PCV). Procedures: A total of 62 eyes of 62 patients who had completed at least 2 years of follow-up were retrospectively reviewed; 19 eyes received PDT only, 23 had anti-VEGF therapy only and 20 underwent combination therapy. Best-corrected visual acuity at baseline and each follow-up visit was investigated as a primary outcome measure. Results: At year 2, the PDT and combination groups maintained significant visual improvement (p = 0.041 and p = 0.021), whereas the anti-VEGF group failed to do so (p = 0.673) when compared with the baseline. The combination group showed better visual outcome during follow-up, and significantly better visual outcome than the PDT group (p = 0.038) and the anti-VEGF group (p = 0.012) at year 2. Conclusions: Combination therapy leads to significantly better visual outcome than PDT and anti-VEGF monotherapy and is therefore a superior method for treating PCV, with a favorable visual outcome.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hae Min(강혜민)
Koh, Hyoung Jun(고형준) ORCID logo https://orcid.org/0000-0002-5932-8516
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