Cited 21 times in
Two-year outcome after combination theraphy for polypoidal choroidal vasculopathy: comparison with photodynamic monotheraphy and anti-vascular endothelial growth factor monotherapy
DC Field | Value | Language |
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dc.contributor.author | 강혜민 | - |
dc.contributor.author | 고형준 | - |
dc.date.accessioned | 2015-01-06T16:23:27Z | - |
dc.date.available | 2015-01-06T16:23:27Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0030-3755 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98016 | - |
dc.description.abstract | Purpose: To compare treatment outcomes of photodynamic therapy (PDT), anti-vascular endothelial growth factor (VEGF) therapy and PDT combined with anti-VEGF therapy for polypoidal choroidal vasculopathy (PCV). Procedures: A total of 62 eyes of 62 patients who had completed at least 2 years of follow-up were retrospectively reviewed; 19 eyes received PDT only, 23 had anti-VEGF therapy only and 20 underwent combination therapy. Best-corrected visual acuity at baseline and each follow-up visit was investigated as a primary outcome measure. Results: At year 2, the PDT and combination groups maintained significant visual improvement (p = 0.041 and p = 0.021), whereas the anti-VEGF group failed to do so (p = 0.673) when compared with the baseline. The combination group showed better visual outcome during follow-up, and significantly better visual outcome than the PDT group (p = 0.038) and the anti-VEGF group (p = 0.012) at year 2. Conclusions: Combination therapy leads to significantly better visual outcome than PDT and anti-VEGF monotherapy and is therefore a superior method for treating PCV, with a favorable visual outcome. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 86~93 | - |
dc.relation.isPartOf | OPHTHALMOLOGICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Angiogenesis Inhibitors/administration & dosage | - |
dc.subject.MESH | Antibodies, Monoclonal, Humanized/administration & dosage* | - |
dc.subject.MESH | Bevacizumab | - |
dc.subject.MESH | Choroid/blood supply | - |
dc.subject.MESH | Choroid Diseases/diagnosis | - |
dc.subject.MESH | Choroid Diseases/drug therapy* | - |
dc.subject.MESH | Fluorescein Angiography | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Fundus Oculi | - |
dc.subject.MESH | Infusions, Intravenous | - |
dc.subject.MESH | Intravitreal Injections | - |
dc.subject.MESH | Photochemotherapy/methods* | - |
dc.subject.MESH | Photosensitizing Agents/administration & dosage | - |
dc.subject.MESH | Porphyrins/administration & dosage* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Tomography, Optical Coherence | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/antagonists & inhibitors* | - |
dc.subject.MESH | Visual Acuity | - |
dc.title | Two-year outcome after combination theraphy for polypoidal choroidal vasculopathy: comparison with photodynamic monotheraphy and anti-vascular endothelial growth factor monotherapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학) | - |
dc.contributor.googleauthor | Kang H.M. | - |
dc.contributor.googleauthor | Koh H.J. | - |
dc.identifier.doi | 10.1159/000354546 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00095 | - |
dc.contributor.localId | A00152 | - |
dc.relation.journalcode | J02431 | - |
dc.identifier.eissn | 1423-0267 | - |
dc.identifier.pmid | 24135710 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/354546 | - |
dc.subject.keyword | Anti-vascular endothelial growth factor therapy | - |
dc.subject.keyword | Combination therapy | - |
dc.subject.keyword | Photodynamic therapy | - |
dc.subject.keyword | Polypoidal choroidal vasculopathy | - |
dc.contributor.alternativeName | Kang, Hae Min | - |
dc.contributor.alternativeName | Koh, Hyoung Jun | - |
dc.contributor.affiliatedAuthor | Kang, Hae Min | - |
dc.contributor.affiliatedAuthor | Koh, Hyoung Jun | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 231 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 86 | - |
dc.citation.endPage | 93 | - |
dc.identifier.bibliographicCitation | OPHTHALMOLOGICA, Vol.231(2) : 86-93, 2014 | - |
dc.identifier.rimsid | 54330 | - |
dc.type.rims | ART | - |
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