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수술전에 시행한 PET에서 갑상선 유두상암의 FDG 섭취양상

Other Titles
 FDG Uptake in the Pathologically Proven Papillary Thyroid Cancer 
Authors
 김태성  ;  윤미진  ;  이종두  ;  조응혁 
Citation
 NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.41(1) : 22-29, 2007 
Journal Title
 NUCLEAR MEDICINE AND MOLECULAR IMAGING 
ISSN
 1869-3474 
Issue Date
2007
Abstract
Purpose: Metastatic thyroid cancers with I-131 uptake have been known to show no increase of FDG uptake whereas those without I-131 uptake tend to demonstrate increased uptake on PET. In this study, we evaluated the degree of FDG uptake in primary thyroid cancers of papillary histology before surgery. Material & Methods: Forty FDG PET studies were performed on the patients who had papillary cancer proven by fine needle aspiration. The degree of FDG uptake was visually categorized as positive or negative (positive if the tumor showed discernible FDG; negative if the tumor didn't) and the peak standard uptake value (peak SUV) of the papillary thyroid cancer (PTC) were compared with the size of PTC. Results: The mean size of 26 PTC with positive FDG uptake was 1.9±1.4 cm(0.5~5 cm). In 13 PTC with negative FDG uptake, the mean size of those was 0.5±0.2 cm (0.2~0.9 cm). All PTC larger than 1cm (2.5±1.4 cm, 1~5 cm) have positive FDG uptake (peak SUV=6.4±5.7, 1.7~22.7). Among the micropapillary thyroid cancer (microPTC; PTC smaller than 1cm), 8 microPTC show positive FDG uptake(peak SUV=2.9±1.3, 1.7~5.5), while 13 microPTC show negative finding(peak SUV=1.3±0.2, 1.1~1.7). The size of microPTC with positive FDG uptake is significantly larger than that of microPTC with negative FDG uptake (0.7±0.1 cm vs 0.4±0.2 cm, p=0.01). Conclusion: All PTCs larger than 1cm show positive FDG uptake in our study. In other words, thyroid lesions larger than 1cm with negative FDG uptake are unlikely to be PTC. So far, only poorly differentiated thyroid cancers are known to show increased FDG uptake. Our results seem to be contradictory to what is known in the literature. Further study is needed to understand better the significance of increased FDG uptake in PTC in relation to expression of NIS and GLUT.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Tae Sung(김태성)
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Lee, Jong Doo(이종두)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97911
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