TcpO2를 이용한 당뇨병성 신경병증 환자의 조기진단

Abstract

PDiabetic neuropathy is one of the most common diabetes related complications including diabetic nephropathy and retinopahty. In clinical practices, nerve conduction velocity (NCV) has been used as a standard method for diagnosing diabetic neuropathy. However, it applies maximum current of 100mA to nerves causing stress and pain to patients. In this study, as a non-invasive method, TcpO₂ was utilized to investigate the difference and relationship between TcpO₂ and SpO₂ of normal and diabetic neuropathy subjects. In addition, a new method of diagnosing diabetic neuropathy using TcpO₂ is suggested. 50 normal subjects and 50 diabetic patients with neuropathy diagnosed by NCV participated in this study. Parameters used in this study were TcpO₂, TcpCO₂, and SpO₂. As a result of the TcpO₂ measurements, statistical significances were found from TcpO₂ of hands and feet from normal and patients group(p＜0.01). SpO₂ measured from index finger of normal and patient groups showed no statistical significance(p>0.05). On the other hand, SpO₂ measured from great toes of normal and patient groups showed statistical significance(p＜0.01). Correlation coefficient between SpO₂ of finger and TcpO₂ of hand was 0.400 (p＜0.01) and SpO₂ of toe and TcpO₂ of foot was 0.471(p＜0.01). Both correlation values were statistically significant. Sensitivities and specificities of the TcpO₂ method were found to be 66 % and 92 %, respectively. If the suggested TcpO₂ method is used periodically, prevention and early diagnosis of diabetic neuropathy would be possible.