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인체 지방유래세포의 근육세포 분화 가능성

Other Titles
 Myogenic Potential of Human Adipose-Tissue-Derived Cells 
 박윤길  ;  문재호  ;  김동수  ;  김균태  ;  김지향  ;  도병록  ;  이은영 
 Journal of the Korean Association of EMG-Electrodiagnostic Medicine, Vol.9(1) : 69-74, 2007 
Journal Title
Journal of the Korean Association of EMG-Electrodiagnostic Medicine(대한 근전도 전기진단의학회지)
Issue Date
Objectives: Cell therapy has been extensively studied as a gene complementation approach in such genetic diseases as Duchenne muscular dystrophy (DMD). Adipose tissue has recently been identified as an alternative, uniquely abundant and accessible source of pluripotent cells. In the present work we investigated myogenic potentials of adipose-tissue-derived cells (ATDCs) as mesenchymal stem cells (MSCs). Methods: Human ATDCs were obtained by liposuction and cultured in three different media; control, myogenic and conditioned media. The following observation was made to evaluate differentiation with using immunoflurescence study and western blotting. Results: Conversion of ATDCs to a myogenic phenotype is observed by indirect immunoflurescence study of MyoD and Myf-5 in regardless of media type. However, secondary myogenic regulatory factors (Myf-6 and myogenin) and desmin are negative in all different culture condition. Conclusion: Our findings suggest that human adipose-tissue-derived cells might have a mesencymal stem cell population and myogenic potentials. Since human adipose tissue is plentiful, easily harvested in large quantity under local anesthesia with little patient discomfort, it may be a good source of an alternative cell therapy for DMD patients.
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1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Moon, Jae Ho(문재호)
Park, Yoon Ghil(박윤길) ORCID logo https://orcid.org/0000-0001-9054-5300
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