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Raf-1 and protein kinase B regulate cell survival through the activation of NF-κB in hepatitis B virus X-expressing cells

Authors
 Hae-Ryun Um  ;  Won-Chung Lim  ;  Hyeseong Cho  ;  Jeon Han Park  ;  Sun Park  ;  Sun-Young Chae 
Citation
 VIRUS RESEARCH, Vol.125(1) : 1-8, 2007 
Journal Title
 VIRUS RESEARCH 
ISSN
 0168-1702 
Issue Date
2007
Abstract
We previously demonstrated that activation of NF-κB by the hepatitis B virus X (HBx) gene plays an important role in cell survival. In the present study, we explored the upstream mediators of NF-κB activation and their correlations with cell survival. XTT assays and colony generation assays revealed that inhibition of NF-κB activation indeed increased cell death in HBx-expressing cells. Utilizing inactivating mutants of signal transducers, we showed that dominant negative mutants of stress-activated protein kinase/extracellular signal-regulated kinase (SEK1) or PKCα significantly diminished the HBx-mediated NF-κB activation. However, neither of these mutants significantly affected the cell survival in colony generation assays. In contrast, inactivating mutants of Raf-1 or PKB (protein kinase B)/Akt abrogated the HBx-mediated NF-κB activation and also suppressed the cell survival. Our results suggest that the Raf-1 or PKB-mediated NF-κB activation promotes cell survival in HBx-expressing cells.
Full Text
http://www.sciencedirect.com/science/article/pii/S0168170206003601
DOI
10.1016/j.virusres.2006.11.007
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Jeon Han(박전한) ORCID logo https://orcid.org/0000-0001-9604-3205
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97446
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