Cited 14 times in
Raf-1 and protein kinase B regulate cell survival through the activation of NF-κB in hepatitis B virus X-expressing cells
DC Field | Value | Language |
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dc.contributor.author | 박전한 | - |
dc.date.accessioned | 2014-12-21T17:21:48Z | - |
dc.date.available | 2014-12-21T17:21:48Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0168-1702 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97446 | - |
dc.description.abstract | We previously demonstrated that activation of NF-κB by the hepatitis B virus X (HBx) gene plays an important role in cell survival. In the present study, we explored the upstream mediators of NF-κB activation and their correlations with cell survival. XTT assays and colony generation assays revealed that inhibition of NF-κB activation indeed increased cell death in HBx-expressing cells. Utilizing inactivating mutants of signal transducers, we showed that dominant negative mutants of stress-activated protein kinase/extracellular signal-regulated kinase (SEK1) or PKCα significantly diminished the HBx-mediated NF-κB activation. However, neither of these mutants significantly affected the cell survival in colony generation assays. In contrast, inactivating mutants of Raf-1 or PKB (protein kinase B)/Akt abrogated the HBx-mediated NF-κB activation and also suppressed the cell survival. Our results suggest that the Raf-1 or PKB-mediated NF-κB activation promotes cell survival in HBx-expressing cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1~8 | - |
dc.relation.isPartOf | VIRUS RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Raf-1 and protein kinase B regulate cell survival through the activation of NF-κB in hepatitis B virus X-expressing cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Hae-Ryun Um | - |
dc.contributor.googleauthor | Won-Chung Lim | - |
dc.contributor.googleauthor | Hyeseong Cho | - |
dc.contributor.googleauthor | Jeon Han Park | - |
dc.contributor.googleauthor | Sun Park | - |
dc.contributor.googleauthor | Sun-Young Chae | - |
dc.identifier.doi | 10.1016/j.virusres.2006.11.007 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01641 | - |
dc.relation.journalcode | J02786 | - |
dc.identifier.eissn | 1872-7492 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0168170206003601 | - |
dc.contributor.alternativeName | Park, Jeon Han | - |
dc.contributor.affiliatedAuthor | Park, Jeon Han | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 125 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 8 | - |
dc.identifier.bibliographicCitation | VIRUS RESEARCH, Vol.125(1) : 1-8, 2007 | - |
dc.identifier.rimsid | 55885 | - |
dc.type.rims | ART | - |
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